Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.

By Claudio Franceschi, J. Campisi. The journals of gerontology. Series A, Biological sciences and medical sciences, 2014

3,497 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/aeb6529afbac3af0ec16264d68bae9ecab982526

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Siddhartha Jaiswal
2. Benjamin L. Ebert
3. Jesús Gil
4. Claudio Franceschi
5. Luigi Ferrucci
6. J. Campisi
7. Paolo Garagnani
8. Domhnall McHugh

In Molecular Biology

1. Jesús Gil
2. J. Campisi
3. M. Demaria
4. Benjamin L. Ebert
5. Siddhartha Jaiswal
6. Domhnall McHugh
7. Claudio Franceschi
8. Manuel Serrano

In Physiology

1. J. Campisi
2. Jesús Gil
3. M. Demaria
4. Manuel Serrano
5. Domhnall McHugh
6. Benjamin L. Ebert
7. Siddhartha Jaiswal
8. M. Collado

Citations in the corpus

• Aging in COVID-19: Vulnerability, immunity and intervention (2020, neutral): “Inflammaging is well documented and can be derived from senescence-associated secretory phenotype (SASP), persistent viral infection such as CMV, and other potential sources (Chen et al., 2019; Franceschi et al., 2000; Franceschi and Campisi, 2014).”
• Measuring biological aging in humans: A quest (2019, background): “Interestingly, all of the “hallmarks of aging” cited above directly or indirectly cause an inflammatory state, suggesting that the pro-inflammatory state observed in many older persons may reflect the burden of biological aging (Ferrucci et al., 2005; Franceschi & Campisi, 2014; Fulop et al., 2018).”
• LINE-1 derepression in senescent cells triggers interferon and inflammaging (2019, neutral): “Given Sterile inflammation, also known as inflammaging, is a hallmark of aging and a contributing factor to many age-related diseases 31,32 .”
• Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases (2018, background): “Aging promotes the hypercoagulable state and increased the risk of arterial and venous thrombosis in the elderly (Franceschi and Campisi, 2014).”
• A proteomic atlas of senescence-associated secretomes for aging biomarker development (2019, background): “Increased circulating DAMPs are hypothesized to play a role in aging 415 [54,55], particularly the age-related inflammation termed ‘inflammaging’ [56].”
• Cellular Senescence: Defining a Path Forward. (2019, background): “SASP factors mediate developmental senescence (Mun˜oz-Espı´n et al., 2013; Storer et al., 2013), wound healing (Demaria et al., 2014), and tissue plasticity (Mosteiro et al., 2016) and also contribute to persistent chronic inflammation (known as inflammaging) (Franceschi and Campisi, 2014).”
• Inflammaging and 'Garb-aging'. (2017, background): “Local propagation can be particularly important in pathologies such as cancer in the elderly, where a systemic inflammaging is present [19,20,68].”