Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
By Bee Ling Tan, M. E. Norhaizan, Winnie-Pui-Pui Liew, Heshu Sulaiman Rahman. Frontiers in Pharmacology, 2018
964 citations recorded by the source corpus.
Aging is the progressive loss of organ and tissue function over time. Growing older is positively linked to cognitive and biological degeneration such as physical frailty, psychological impairment, and cognitive decline. Oxidative stress is considered as an imbalance between pro- and antioxidant species, which results in molecular and cellular damage. Oxidative stress plays a crucial role in the development of age-related diseases. Emerging research evidence has suggested that antioxidant can control the autoxidation by interrupting the propagation of free radicals or by inhibiting the formation of free radicals and subsequently reduce oxidative stress, improve immune function, and increase healthy longevity. Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways. Therefore, the role of molecules with antioxidant activity that promote healthy aging and counteract oxidative stress is worth to discuss further. Of particular interest in this article, we highlighted the molecular mechanisms of antioxidants involved in the prevention of age-related diseases. Taken together, a better understanding of the role of antioxidants involved in redox modulation of inflammation would provide a useful approach for potential interventions, and subsequently promoting healthy longevity.
Subfields: Biochemistry, Molecular Biology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/5e730c452d55dd5f1aff6be48ca84f9adb15e138
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- B. Yeskaliyeva
- P. Chaudhary
- A. Docea
- D. Calina
- Pracheta Janmeda
- A. F. Abdull Razis
- B. Modu
- Javad Sharifi‐Rad
Citations in the corpus
- Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases (2023, background): “A sole molecule of ß-carotene is determined to eliminate around 1,000 of singlet oxygen with the help of a physical mechanism which involves the transfer of energy before it gets oxidized and loses its antioxidant activity (Tan et al., 2018).”