Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

By Shenyuan L. Zhang, Andriy V. Yeromin, Xiang-Hong Zhang, Ying Yu, O. Safrina, A. Penna, J. Roos, K. Stauderman, M. Cahalan. Proceedings of the National Academy of Sciences of the United States of America, 2006

879 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/ae26f6d5a338c8b3f49700f7742ab41059dcbcd9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Stephen H. Bryant
2. P. Hogan
3. M. Prakriya
4. Benjamin A. Shoemaker
5. Siqian He
6. Jiyao Wang
7. Jian Zhang
8. S. Feske

In Plant Science

1. T. Balla
2. M. Prakriya

In Sensory Systems

1. M. Prakriya
2. S. Feske
3. Anjana Rao
4. P. Hogan
5. T. Balla
6. R. Lewis

Citations in the corpus

• The endoplasmic reticulum: structure, function and response to cellular signaling (2015, background): “At these regions, clustered STIM1 traps plasma membrane-diffusing Orai1 subunits [35, 36] and assembles them into active Ca 2 ? release-activated channels (CRAC) allowing for uptake of extracellular Ca 2 ? into the ER lumen to restore Ca 2 ? levels [37–39].”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “This was followed within a year by the discovery of the Orai1 protein as the channel component of ICRAC, the highly Ca(2) -selective current representing the major form of SOCE (435, 1635, 1802).”
• Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “…and have contributed to discoveries of mechanisms of axon guidance as well as mitochondrial involvement in oxidative stress and aging (Ayyadevara et al., 2007; Hamamichi et al., 2008; Hamilton et al., 2005; Ichishita et al., 2008; Lee et al., 2003; Schmitz et al., 2007; Zhang et al., 2006).”
• PubChem BioAssay: 2014 update (2013, background): “Many of these newly added siRNA datasets are associated with recent publications in journals such as Nature Cell Biology (9–11), Genome Research (12), J Virol (13), Cancer Research (14), PNAS (15,16), Nature (17–19), Science (20,21) and Nature Genetics (22).”
• Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance (2008, background): “The drosophila protein Orai (encoded by olf186-F ), identified as an essential regulator of store-operated Ca 2+ influx by a series of genome-wide drosophila RNA-mediated interference screen”