The endoplasmic reticulum: structure, function and response to cellular signaling

By D. Schwarz, Michael D. Blower. Cellular and Molecular Life Sciences, 2015

1,406 citations recorded by the source corpus.

The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct domains; consisting of tubules, sheets and the nuclear envelope. Several proteins that contribute to the overall architecture and dynamics of the ER have been identified, but many questions remain as to how the ER changes shape in response to cellular cues, cell type, cell cycle state and during development of the organism. Here we discuss what is known about the dynamics of the ER, what questions remain, and how coordinated responses add to the layers of regulation in this dynamic organelle.

Subfields: Cell Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/1da8cdf40c7a28378d4620f8d1166590123270a1

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1. Jeremy E. Coate
2. N. Melnikova
3. M. Savvateeva
4. J. Doyle
5. A. Dmitriev
6. A. Kudryavtseva
7. A. Snezhkina
8. G. Krasnov

Citations in the corpus

• Polyploidy, the Nucleotype, and Novelty: The Impact of Genome Doubling on the Biology of the Cell (2019, background): “Peripheral ER variation among cell types is also discussed by Schwarz and Blower (2016)—for example, in cells that specialize in protein secretion, ribosome-rich sheets (formerly called “rough ER”) predominate, whereas in cells involved in calciumsignaling and lipid synthesis, tubules (“smooth ER”)…”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “The endoplasmic reticulum (ER) has many general cellular functions, such as protein folding, synthesis, transport, and posttranslational modifications, as well as lipid metabolism and calcium storage [62].”