p16INK4a induces an age-dependent decline in islet regenerative potential

By J. Krishnamurthy, M. R. Ramsey, K. Ligon, C. Torrice, A. Koh, S. Bonner-Weir, N. Sharpless. Nature, 2006

1,031 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/ae05049b3693e5d602dd7ff82ef78895c0f71a4b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. S. Baylin
2. Peter A. Jones
3. Jesús Gil
4. N. Sharpless
5. M. Blasco
6. Leif Groop
7. K. Helin
8. C. Ling

In Molecular Biology

1. K. Helin
2. S. Baylin
3. Peter A. Jones
4. A. Bracken
5. Manuel Serrano
6. M. Blasco
7. S. Morrison
8. N. Sharpless

In Surgery

1. William Y. Kim
2. N. Sharpless
3. Manuel Serrano
4. M. Demaria

Citations in the corpus

• FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “, p16) that appear to suppress cancer at the cost of tissue-resident stem cells and therefore may contribute to decreased regenerative potential during the aging process (Krishnamurthy et al., 2006; Molofsky et al., 2006).”
• Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes (2009, background): “In support of this, an increased expression of Ink4a/Arf (Cdkn2a locus) was associated with reduced -cell regeneration in aging mice (82).”
• Mechanisms of stem cell self-renewal. (2009, background): “…activities and leading to cancer. overexpression of p15Ink4b/p16Ink4a/p19Arf and p53 increases mouse life span (Matheu et al. 2007), even though loss of p16Ink4a increases stem cell function in multiple tissues during aging ( Janzen et al. 2006, Krishnamurthy et al. 2006, Molofsky et al. 2006).”
• Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “Surprisingly, although p16INK4a expression drove a decline in β cell regenerative capacity and predisposed mice to mild diabetes (Krishnamurthy et al., 2006; Chen et al., 2009), senescent β islets increased insulin secretion, making it unclear how senescence contributes to maintain glucose homeostas”
• The biology of cancer stem cells. (2007, background): “Recent studies showed that p16 Ink4a plays a role in stem cell senescence in the blood, brain, and pancreatic islet cells ( Janzen et al. 2006, Krishnamurthy et al. 2006, Molofsky et al. 2006).”