Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells.
By Yuren Wei, Dong Wang, F. Topczewski, M. Pagliassotti. American Journal of Physiology. Endocrinology and Metabolism, 2006
707 citations recorded by the source corpus.
Subfields: Biochemistry, Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/adfdd5ec9d92cda8a5b131cebfe06c0c016f6084
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Citations in the corpus
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “For example, the metabolism and trafficking of free fatty acids are abnormal in obesity, and excess free fatty acids induce ER stress in hepatocytes, cardiomyoblasts, pancreatic b cells, and macrophages (Borradaile et al., 2006; Kharroubi et al., 2004; Wei et al., 2006).”
- Initiation and execution of lipotoxic ER stress in pancreatic β-cells (2008, background): “The other primers have been reported elsewhere (Cnop et al., 2007a; Kharroubi et al., 2004; Marchetti et al., 2007; Pirot et al., 2006; Welsh et al., 2005).”
- Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease (2018, background): “Impaired activity of cytochrome C [35] Production of reactive aldehydes (MDA, 4-HNE) through lipid peroxidation [43]”
- Increased de novo Lipogenesis is a Distinct Characteristic of Individuals with Nonalcoholic Fatty Liver Disease (2013, neutral): “Lastly, the primary product of lipogenesis is palmitate, a saturated FA,(24) which may promote inflammation and endoplasmic reticulum stress.(53,54) The strengths of the present study included the comprehensive assessments of characteristics that affect intrahepatic TG levels and the similarity betw”
- Lipid signalling in disease (2008, background): “The accumulation of excess lipid, in particular saturated fatty acids and sterols, might induce cellular damage through stress on the membranes of lipid-metabolizing organelles, especially the endoplasmic reticulum (ER) and possibly mitochondri”
- A ceramide-centric view of insulin resistance. (2012, background): “However, to these authors’ knowledge, the only study investigating the role of ceramide in ER stress in insulin sensitive tissues found that inhibitors of ceramide synthesis did not prevent palmitate-induced ER stress in the liver (Wei et al., 2006).”
- Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c (2010, background): “For instance, saturated fatty acids such as palmitate are excellent activators of an ER stress in several cellular models including hepatocytes [83].”
- Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. (2012, background): “Enhanced rates of fatty acid oxidation yield lipid peroxides and free radicals that may cause macromolecular oxidative injury, mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis [83,84].”