Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c

By P. Ferré, F. Foufelle. Diabetes, obesity and metabolism, 2010

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Triglyceride metabolism in the liver (2017, neutral): “The rate of incorporation of DNL-synthesized FA into VLDL-TG is increased in normal subjects in the setting of high-carbohydrate diet (223, 224), alcohol consumption and infectious states (88), and is positively correlated with increased plasma VLDL-TG content (223).”
Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “Insulin induces SREBP-1c maturation via a proteolytic mechanism started in the endoplasmic reticulum (ER), wherein hepatic IR is highly associated with hepatic steatosis.(118) Over-expression of liver SREBP-1c has been described in several IR models of including IRS2 knockout,(119) lipodystrophic an”
Mechanisms of Hepatic Triglyceride Accumulation in Nonalcoholic Fatty Liver Disease (2013, neutral): “Lipogenesis is controlled primarily at the transcriptional level [32, 33].”