Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

By M. Masarone, V. Rosato, M. Dallio, A. Gravina, Andrea Aglitti, C. Loguercio, A. Federico, M. Persico. Oxidative Medicine and Cellular Longevity, 2018

594 citations recorded by the source corpus.

Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning, and fibrosis (namely, nonalcoholic steatohepatitis) up to severe liver disease and eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology of fatty liver and its progression is influenced by multiple factors (environmental and genetics), in a “multiple parallel-hit model,” in which oxidative stress plays a very likely primary role as the starting point of the hepatic and extrahepatic damage. The aim of this review is to give a comprehensive insight on the present researches and findings on the role of oxidative stress mechanisms in the pathogenesis and pathophysiology of NAFLD. With this aim, we evaluated the available data in basic science and clinical studies in this field, reviewing the most recent works published on this topic.

Subfields: Cell Biology, Endocrinology, Diabetes and Metabolism, Epidemiology

View Paper: https://www.semanticscholar.org/paper/1af89a2536995b9e1bcb8204e4382f8695d88213

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In Cell Biology

1. Gerald I. Shulman
2. S. Friedman

In Endocrinology, Diabetes and Metabolism

1. S. Friedman
2. Gerald I. Shulman
3. R. Loomba

In Epidemiology

1. S. Friedman
2. Gerald I. Shulman
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4. Y. Saiman
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Citations in the corpus

• Mechanisms and disease consequences of nonalcoholic fatty liver disease (2021, background): “NASH-related mechanisms of HCC NAFLD and NASH are characterized by enhanced lipid accumulation in hepatocytes that can generate pathogenic drivers of carcinogenesis, in particular oxidative DNA damage (Masarone et al., 2018; Tanaka et al., 2013).”
• Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections (2023, background): “Among the metabolic alterations and pathologies promoted by hyperglycemia in the organs and tissues referred to above in the mentioned order, the liver shows the non-alcoholic fatty liver disease [30] characterized by increased oxidative stress, inflammation, the development of insulin resistance an”