Building epithelial architecture: insights from three-dimensional culture models

By L. O’Brien, M. Zegers, Keith E. Mostov. Nature reviews. Molecular cell biology, 2002

643 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/adca8bfca4e0effc0fb0842fe8105492afb18e76

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Zena Werb
2. Keith E. Mostov
3. Peter Friedl
4. M. Egeblad
5. E. Nakasone
6. Valerie M. Weaver
7. Manuel Théry
8. Micah Dembo

In Cell Biology

1. Valerie M. Weaver
2. Peter Friedl
3. Zena Werb
4. Keith E. Mostov
5. David M. Bryant
6. M. Egeblad
7. E. Nakasone
8. W. Nelson

In Oncology

1. M. Egeblad
2. E. Nakasone
3. Peter Friedl
4. Valerie M. Weaver
5. Zena Werb
6. J. Brugge
7. Jayanta Debnath
8. Keith E. Mostov

Citations in the corpus

• From cells to organs: building polarized tissue (2008, background): “Although almost every eukaryotic cell is spatially asymmetric or polarized, polarity must be coordinated in space and time for individual cells to form a tissu”
• Adaptation of core mechanisms to generate cell polarity (2003, background): “Although full development of apicobasal polarity requires organization cues from both cell–cell and cell–extracellular matrix adhesion”
• Tensional homeostasis and the malignant phenotype. (2005, background): “Three-dimensional ECM culture models have highlighted the importance of matrix compliance for tissue-specific differentiation and imply that cells in 3D might respond differently to growth, polarity, and death stimuli (O’Brien et al., 2002; Paszek and Weaver, 2004; Wang et al., 1998; Weaver et al., ”
• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “This polarization plays an important role in controlling epithelial proliferation, migration, adhesion, differentiation, and cell death (O’Brien et al., 2002).”
• The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. (2002, background): “Howspace is a hallmark of early epithelial tumors, such as ever, a lumen can also be created independently of atypical hyperplasias and ductal carcinoma in situ apoptosis (O’Brien et al., 2002).”
• Micropatterning as a tool to decipher cell morphogenesis and functions (2010, background): “For example, non-transformed mammalian breast cancer cells grown in 3D culture systems based on basement membrane components such as Matrigel, can selfassemble to form growth-arrested acini-like structures that closely reproduce the glandular epithelium architecture (O’Brien et al., 2002).”
• Prespecification and plasticity: shifting mechanisms of cell migration. (2004, background): “The rear of the leading cell(s) maintain the adhesive interaction with other cells, so the retraction of the trailing edge has an important modification: as it glides along the ECM structure, neighboring cells are dragged forward along the established migration track by means of cell–cell adhesion [”