Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.

By Elisabeth B. Binder, R. Bradley, Wei Liu, M. Epstein, T. C. Deveau, Kristina B. Mercer, Yilang Tang, Charles F. Gillespie, Christine Marcelle Heim, C. Nemeroff and 3 more. Journal of the American Medical Association (JAMA), 2008

1,306 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Clinical Psychology

View Paper: https://www.semanticscholar.org/paper/ad909ca1aa67b7fa8a5e7cc745e773d2e0fba820

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Citations in the corpus

Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “There is also growing evidence that such variation explains variability in how early stress affects mental health (Belsky & Pluess, 2009; Binder et al., 2008; R. G. Bradley et al., 2008; Caspi et al., 2002; Gillespie, Phifer, Bradley, & Ressler, 2009).”
The Role of Early Life Stress as a Predictor for Alcohol and Drug Dependence (2010, background): “…been published showing interactive effects between stress genes and childhood maltreatment on depression, PTSD, and suicidal behavior (for example: Binder et al. 2008, 2010; Bradley et al. 2008; Caspi et al. 2010 (review); Heim et al. 2009; Ressler et al. 2010; Roy et al. 2010; Polanczyk et al.…”
Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. (2016, background): “Indeed, four SNPs of the FKBP5 gene interact with 70 of child abuse to predict adult PTSD symptoms (Binder et al., 2008).”
Early Life Programming and Neurodevelopmental Disorders (2010, background): “Genetic polymorphisms of the CRF receptor 1 and of FK506 binding protein 5, a gene that codes a glucocorticoid receptor (GR) co-chaperone protein, have recently been implicated in the child abuse-associated increase in vulnerability to major depression and posttraumatic stress disorder, respectively”
Psychobiology and molecular genetics of resilience (2009, neutral): “Interestingly, four SNPs of FKBP5 (rs9296158, rs3800373, rs1360780 and rs9470080), a gene that codes for a 'chaperone' protein that regulates GR sensitivity, were found to interact with the severity of childhood abuse in the prediction of PTSD symptoms in adult”
Understanding resilience (2013, background): “…2013 | Volume 7 | Article 10 | 1 BEHAVIORAL NEUROSCIENCE is involved in the modulation of glucocorticoid receptor (GR) activity and thereby glucocorticoid signaling, was also found to interact with child abuse through its four SNPs to predict severity of adult PTSD symptoms (Binder et al., 2008).”
“The Biological Effects of Childhood Trauma” (2014, neutral): “Cross-sectional studies have also found interaction for adults who carry the minor FKBP5 allele and have child maltreatment histories as they have increased rates of depression [94], PTSD [95, 96], and suicide risk [97].”
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017, background): “Importantly, SNPs in the FKBP5 gene that are associated with higher FKBP5-mRNA induction upon cortisol release (rs1360780, rs9296158, rs3800373, and rs9470080) are also associated with increased PTSD symptom severity in those with high levels of child abuse (Binder et al, 2008).”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “In addition, recent findings of gene-by-environment interactions in PTSD (Binder et al, 2008) also point toward the possibility that early childhood experience might modify fear/anxiety neurocircuitry and contribute to the development of anxiety disorders.”
Posttraumatic Stress Disorder (2015, background): “Different single nucleotide polymorphisms of the gene encoding a chaperone protein that modulates the transcriptional effects of the glucocorticoid receptor (FKBP5) have been associatedwith an increased risk of developing PTSD among children exposed to physical and sexual abuse.(29) In addition, a r”
Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. (2016, background): “FKBP5 single nucleotide polymorphisms have additionally been shown to interact with early trauma to predict both PTSD and major depression (36,37), possibly through involvement of allelespecific, environmentally dependent changes in methylation of specific cytosine-phosphate-guanine (CpG) sites (38)”
The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. (2009, background): “In fact, in healthy controls, the high-induction alleles are also associated with a relative GR resistance (Binder et al., 2008).”