Early Life Programming and Neurodevelopmental Disorders
By T. Bale, Tallie Z. Baram, Alan S. Brown, J. Goldstein, Thomas R. Insel, Mark I. McCarthy, C. Nemeroff, T. Reyes, R. Simerly, E. Susser and 1 more. Biological Psychiatry, 2010
936 citations recorded by the source corpus.
For more than a century, clinical investigators have focused on early life as a source of adult psychopathology. Early theories about psychic conflict and toxic parenting have been replaced by more recent formulations of complex interactions of genes and environment. Although the hypothesized mechanisms have evolved, a central notion remains: early life is a period of unique sensitivity during which experience confers enduring effects. The mechanisms for these effects remain almost as much a mystery today as they were a century ago. Recent studies suggest that maternal diet can program offspring growth and metabolic pathways, altering lifelong susceptibility to diabetes and obesity. If maternal psychosocial experience has similar programming effects on the developing offspring, one might expect a comparable contribution to neurodevelopmental disorders, including affective disorders, schizophrenia, autism, and eating disorders. Due to their early onset, prevalence, and chronicity, some of these disorders, such as depression and schizophrenia, are among the highest causes of disability worldwide according to the World Health Organization 2002 report. Consideration of the early life programming and transcriptional regulation in adult exposures supports a critical need to understand epigenetic mechanisms as a critical determinant in disease predisposition. Incorporating the latest insight gained from clinical and epidemiological studies with potential epigenetic mechanisms from basic research, the following review summarizes findings from a workshop on Early Life Programming and Neurodevelopmental Disorders held at the University of Pennsylvania in 2009.
Subfields: Behavioral Neuroscience, Education, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/52989062e5f0493bd5554aaac9ce644a13ffe709
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Citations in the corpus
- Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. (2016, background): “…(i.e., Newport et al., 2002; Heim et al., 2008a, 2010; Neigh et al., 2009; Nemeroff and Seligman, 2013; and other leaders in the field, including Bale et al., 2010; Baram et al., 2012; Danese and McEwen, 2012; Teicher and Samson, 2013; Rilling and Young, 2014; Veenstra-VanderWeele and Warren,…”
- Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. (2017, background): “mediating the effects of prenatal stress on neurodevelopment in the perinatal period (Bale et al., 2010; Fernández et al., 2013; Grönlund et al., 2011; Jašarević et al., 2015a; Jašarević et al., 2015b; Logan, 2015; O’Mahony et al.; Palagini et al., 2015; Rogers et al., 2016; Stokholm et al., 2016; Z”