Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

By Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Koji Sato, Tatsuro Nakagawa, M. Funata, Mamiko Yamaguchi, S. Namiki, R. Nakayama, M. Tabata and 16 more. Nature, 2010

980 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/ad29996035294bace9d03cb4044db06524593eb9

How researchers see this paper

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In Epidemiology

1. P. Scherer
2. K. Walsh
3. N. Ouchi
4. M. Pinzani
5. E. Tsochatzis
6. S. Summers
7. William L. Holland
8. L. Guarente

In Geriatrics and Gerontology

1. Hung-Chun Chang
2. L. Guarente
3. D. Sinclair
4. M. Haigis
5. Johan Auwerx
6. E. Verdin
7. E. Seto
8. C. Kenyon

In Physiology

1. Hung-Chun Chang
2. P. Scherer
3. N. Ouchi
4. K. Walsh
5. J. Rutkowski
6. S. Summers
7. William L. Holland
8. L. Guarente

Citations in the corpus

• Adipokines in inflammation and metabolic disease (2011, background): “This pathway is associated with insulin sensitivity, and thus disruption of adiponectin receptor 1 expression specifically in muscle cells was shown to prevent these adiponectin-mediated changes and cause insulin resistanc”
• Adiponectin: mechanistic insights and clinical implications (2012, background): “Furthermore, adiponectin has effects on mitochondrial number and oxidative fibre types [42, 45].”
• SIRT1 and other sirtuins in Metabolism (2013, background): “During exercise, the muscle adiponectin receptor is activated and induces expression of SIRT1, AMPK and PGC-1α in a Ca++ dependent manner, which in turn drive fatty acid oxidation and mitochondrial biogenesis [82].”
• The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). (2016, background): “The antioxidant effects of adiponectin are mediated through its receptor AdipoR1, therefore their decreased levels in obesity may have causal roles inmitochondrial dysfunction and insulin resistance [87].”
• AMPK, insulin resistance, and the metabolic syndrome. (2013, neutral): “Adiponectin also induces extracellular calcium influx through the adiponectin receptor 1 (55) and may have effects independent of AMPK.”
• GENeration (2015, neutral): “These preliminary design criteria would consider definition of array storage conventions within the ILLIAC IV processing element memories, and specialized storage schemesand disk mapping criteria for internal file communications and external files used in intermodular communication.”
• Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis Through Adipose Tissue Crosstalk (2016, background): “Furthermore, adipoR1 in skeletal muscle stimulates extracellular Ca2+ influx, increasing cytosolic Ca2+ (Iwabu et al., 2010).”
• The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity (2010, background): “Activation of AMPK has been reported as a downstream readout for these receptor”