Secreted antagonists of the Wnt signalling pathway

By Y. Kawano, R. Kypta. Journal of Cell Science, 2003

1,656 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ac75448f6f17da3cc4ef3c3a118c45e6eb5538b8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Towards an integrated view of Wnt signaling in development (2009, background): “Wifs and Sfrps can directly bind to Wnt proteins in the extracellular space, thereby affecting receptor occupancy and, ultimately, the cellular response (Bovolenta et al., 2008; Kawano and Kypta, 2003).”
Glucocorticoid-induced osteoporosis: pathophysiology and therapy (2007, background): “Glucocorticoids enhance Dickkopf expression and maintain GSK 3-β in an active state, leading ultimately to the inactivation of β-catenin [16, 17, 21].”
Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “Once released into the extracellular milieu, Wnts interact with secreted proteins such as SFRPs and WIF (Kawano and Kypta 2003).”
Emerging roles of Wnts in the adult nervous system (2010, background): “However, Wnt signalling is tightly regulated and a delicate balance between activation and inactivation of canonical and non-canonical signalling is maintained both during development and in the adult brai”
Secreted and transmembrane wnt inhibitors and activators. (2013, background): “Related reviews examining Dkks (Niehrs 2006), sFRPs (Jones and Jomary 2002; Kawano and Kypta 2003; Bovolenta et al. 2008), Cerberus (Belo et al.”
Dorsal-ventral patterning and neural induction in Xenopus embryos. (2004, background): “Secreted Frizzled–related proteins (sFRPs) constitute a large family of Wnt antagonists that encode secreted forms of the amino-terminal, cysteine-rich domain of the Wnt receptor Frizzled (Kawano & Kypta 2003).”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “Extracellular Wnt inhibitors, including the secreted Frizzled-related proteins (SFRPs) and Dickkopf proteins (DKKs), which act at the cell surface to inhibit Wnt signalling through its receptors, have been discovere”
Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Five families of extracellular Wnt antagonists are currently known (Kawano and Kypta, 2003), the secreted frizzled-related protein (sFRP), Wnt inhibitory factor 1 (Wif1), Xenopus Cerberus, Wise and the Dickkopf (Dkk) family of secreted proteins, and the latter will be reviewed here.”
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease (2008, background): “Reviews that centre on Wnt antagonism by SFRPs have recently been published elsewhere (Cadigan and Liu, 2006; Jones and Jomary, 2002; Kawano and Kypta, 2003); here, we discuss new aspects of SFRP activity, and review SFRP structure, expression and interactions with Wnt proteins.”