DNA methylation in cancer: too much, but also too little

By Melanie Ehrlich. Oncogene, 2002

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DNA methylation and cancer. (2004, background): “Hypomethylation usually involves repeated DNA sequences, such as long interspersed nuclear elements, whereas hypermethylation involves CpG islands.(34)”
DNA hypomethylation and human diseases. (2007, background): “The most recent reviews in DNA hypomethylation and disease, commonly referred to within this manuscript, include those by Ehrlich [12,33] and Hoffman and Schulz [31].”
DNA hypomethylation in cancer cells (2009, background): “119 Ehrlich M: Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr. Top. Microbiol. Immunol. 310, 251–274 (2006).”
A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. (2006, background): “Whereas the promoters of many genes are hypermethylated in cancer (32), several DNA repeat sequences, including centromeric and pericentromeric repeats, are usually hypomethylated in cancer (33).”
Cancer epigenetics. (2005, background): “It has long been known that cancer cells undergo changes in 5-methylcytosine distribution including global DNA hypomethylation (5) and the hypermethylation of promoter CpG islands associated with tumor-suppressor genes (6–9).”
Active DNA Demethylation Mediated by DNA Glycosylases (2009, neutral): “In many cancers, bulk genome DNA methylation levels are reduced (22, 25, 104).”