The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

By G. Barbatelli, I. Murano, Lise Madsen, Qin Hao, M. Jimenez, Karsten Kristiansen, J. Giacobino, R. Matteis, S. Cinti. American Journal of Physiology. Endocrinology and Metabolism, 2010

769 citations recorded by the source corpus.

Subfields: Epidemiology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/ac0668a6def6640226253c33fec31b9c08696025

How researchers see this paper

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In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. Mitchell A. Lazar
5. A. Chait
6. Laura J. den Hartigh
7. H. Ohno
8. Jun Wu

In Nutrition and Dietetics

1. J. Flier
2. S. Kajimura

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. Jun Wu
5. Mitchell A. Lazar
6. A. Chait
7. Laura J. den Hartigh
8. H. Ohno

Citations in the corpus

• FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. (2012, background): “In addition, UCP1-positive, brown fat-like cells can emerge in most white fat (white adipose tissue [WAT]) depots upon prolonged cold exposure or b-adrenergic receptor activation (Cousin et al. 1992; Ghorbani and Himms-Hagen 1997; Barbatelli et al. 2010).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “Studies by Cinti and others demonstrated that b-adrenergically induced beige-ing occurs without significant increases in adipocyte proliferation or DNA content (Barbatelli et al., 2010; Himms-Hagen et al., 2000).”
• In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high fat feeding (2012, neutral): “Interestingly, nearly all BA in abdominal WAT were derived de novo, whereas the vast majority of BA in inguinal fat involved conversion of existing WA to a BA phenotype, as previously proposed (Barbatelli et al., 2010; Cinti, 2009).”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “Meanwhile, Cinti’s group has shown that the browning of white fat in response to cold is mainly due to the transdifferentiation of mature white adipocytes into brown adipocytes in mice [45].”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Beige adipocytes were initially thought to arise from transdifferentiation from white adipocytes, with the ability to de-differentiate back into white adipocytes (55, 56).”
• Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “; thus, the plasticity of WAT in response to these stimuli may be due to transdifferentiation of mature white adipocytes into brown adipocyte”
• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “org Volume 125 Number 2 February 2015 (40).”
• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. (2013, neutral): “Detectable BAT volume increased significantly, by 37%, comparable to the changes occurring in rodents (23, 31).”