Widespread occurrence of antisense transcription in the human genome

By R. Yelin, Dvir Dahary, Rotem Sorek, E. Levanon, Orly Goldstein, Avi Shoshan, Alex Diber, S. Biton, Yael Tamir, R. Khosravi and 6 more. Nature Biotechnology, 2003

648 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/abae0eaf89497d09c0676918d2698397c719b72a

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Citations in the corpus

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007, background): “Meanwhile, our understanding of the repertoire of transcriptional events is becoming more complex, with an increasing appreciation of alternative TSSs 32,33 and the presence of non-coding 27,34 and anti-sense transcripts 35,36 .”
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. (2008, background): “The importance of antisense transcription has been stressed by the widespread occurrence of antisense transcripts in the human genome: Between 5% and 10% of all genes have an antisense counterpart (Yelin et al. 2003; Katayama et al. 2005).”
Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome (2004, background): “This raises the question of how the regulation of thousands of human messages proposed by Yelin and colleagues involving antisense transcripts works (Yelin et al. 2003).”
The small RNA profile during Drosophila melanogaster development. (2003, background): “All clonedber of genes are partially overlapping in opposite orienbantam miRNAs begin with the same 5 uridine residuetation in various organisms (Merino et al., 1994; Shendure encoded one nucleotide downstream of the proposed and Church, 2002; Yelin et al., 2003).”
Genome Structure of the Legume, Lotus japonicus (2008, background): “Genome-wide transcriptome analyses have identified a large number of non-coding RNA species being transcribed in the genome.(47,48) Using the previously accumulated information from L.”
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. (2005, background): “This possibility is of particular interest in light of the recent identification of a large number of apparent sense/antisense transcriptional units in eukaryotic genomes, many of which overlap in their 3 UTRs (Shendure and Church 2002; Yelin et al. 2003) and in light of accumulating evidence for th”
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. (2004, background): “Why are thesethan the 8% based on computational analysis (Yelin et al., 2003).”
A census of mammalian imprinting. (2005, background): “Although it has been suggested that antisense transcripts are especially common among imprinted genes [18], recent studies suggest that senseantisense transcript pairs occur in 10‐20% of all autosomal genes [15, 19 ,20].”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “However, considering the high number of sense–antisense paired genes in the genome [78, 79], as well as the ability of some lncRNAs to form R-loops in trans [80], it is likely that other lncRNAs will be identified to regulate gene expression via R-loops.”
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. (2006, background): “It would also be interesting to determine whether Drosha is involved in the metabolism of the abundant sense-antisense RNA pairs identified by recent genomic studies (Chen et al., 2004b; Yelin et al., 2003).”