The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making
By Nasir H. Naqvi, Antoine Bechara. Brain Structure and Function, 2010
600 citations recorded by the source corpus.
We have recently shown that damage to the insula leads to a profound disruption of addiction to cigarette smoking (Naqvi et al., Science 315:531–534, 2007). Yet, there is little understanding of why the insula should play such an important role in an addictive behavior. A broad literature (much of it reviewed in this issue) has addressed the role of the insula in processes related to conscious interoception, emotional experience, and decision-making. Here, we review evidence for the role of the insula in drug addiction, and propose a novel theoretical framework for addiction in which the insula represents the interoceptive effects of drug taking, making this information available to conscious awareness, memory and executive functions. A central theme of this framework is that a primary goal for the addicted individual is to obtain the effects of the drug use ritual upon the body, and representations of this goal in interoceptive terms by the insula contribute to how addicted individuals feel, remember, and decide about taking drugs. This makes drug addiction like naturally motivated behaviors, such as eating and sex, for which an embodied ritual is the primary goal.
Subfields: Experimental and Cognitive Psychology, Psychiatry and Mental health, Social Psychology
View Paper: https://www.semanticscholar.org/paper/e65757b442e8ca34221d71c5b216c5ea950f6f51
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Experimental and Cognitive Psychology
In Psychiatry and Mental health
In Social Psychology
Citations in the corpus
- The Brain on Drugs: From Reward to Addiction. (2015, background): “…since this region is involved in interoceptive awareness, contributes to the conscious awareness of drug craving, and is part of the default mode network (DMN) that enables internal mind wandering, perhaps facilitating rumination about drug use in addicted subjects (Naqvi and Bechara, 2010).”
- Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies (2011, neutral): “The insula has been shown to be important in interoception (Craig, 2002) and taste perception (Pritchard et al., 1999), and may thus be involved in perception of cue-evoked conditioned responses, resulting in a subjective craving for cigarettes (Naqvi & Bechara, 2009; Naqvi & Bechara, 2010).”
- Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “Complementing a network-switching function, insula's role in interoception (Craig, 2002; Craig, 2009), and, by extension, drug addiction (Naqvi and Bechara, 2009, 2010), has been of substantial recent interest.”
- Impact of mindfulness on the neural responses to emotional pictures in experienced and beginner meditators (2011, background): “…involved in addiction, awareness of interoceptive states of urges and pleasure, and reactivity to positive stimuli (amygdala, hippocampus, insula, basal ganglia; Craig, 2004; Everitt et al., 1999; Haruno et al., 2004; Naqvi and Bechara, 2010; Phillips and Ledoux, 1992; Prado-Alcala andWise, 1984).”
- fMRI Reactivity to High-Calorie Food Pictures Predicts Short- and Long-Term Outcome in a Weight-Loss Program (2012, background): “The striatum and insula have also been implicated in both food and drug craving (Garavan et al., 2000; Garavan, 2010; Naqvi et al., 2007; Naqvi and Bechara, 2010; Pelchat et al., 2004).”