Alcoholism: allostasis and beyond.

By G. Koob. Alcoholism: Clinical and Experimental Research, 2003

719 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3bddb5bb5440990077bf58a2a778e200d391b264

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Citations in the corpus

Efficacy and Tolerability of Long-Acting Injectable Naltrexone for Alcohol Dependence: A Randomized Controlled Trial (2005, background): “As a prototypical addictive disorder, alcohol dependence is thought to involve dysfunction of the brain’s reward system with attendant impaired control over drives and motivation.(25) Moreover, treatment may directly conflict with the behaviors and rewards associated with the abused substance.”
Addiction and the brain antireward system. (2008, background): “…that excessive drug taking can cause the dysregulated emotional state that leads to each class of drugs being self-administered as an antidote to dysphoric states and act temporarily as a replacement for a defect in the psychological structure of these individuals caused by the drug (Koob 2003b).”
Allostatic load biomarkers of chronic stress and impact on health and cognition. (2010, background): “…disorders (Kapczinski et al., 2008; McEwen, 2003c, 2004, 2005), anxiety disorders (McEwen, 2002; Schulkin et al., 1994, 1998), and substance-abuse (Koob, 2003; Koob et al., 2004; Koob and Le Moal, 2001; Schulkin, 2003a; Valdez and Koob, 2004; Zimmermann et al., 2007) have been matched by only a…”
The Role of Early Life Stress as a Predictor for Alcohol and Drug Dependence (2010, background): “Addiction to alcohol and drugs has been described as a perpetual cycling of preoccupation and anticipation, binge/ intoxication, and withdrawal/negative affect (Koob 2003).”
Alcohol: Effects on Neurobehavioral Functions and the Brain (2007, background): “A deficiency or absence of the D 2 receptors then predisposes individuals to a high risk for multiple maladaptive behaviors (Koob 2003).”
Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness? (2005, background): “…thought to participate in generating hedonic impact for drug rewards and for natural sensory pleasures such as sweetness (Zhang et al., 1998; Peciña and Berridge, 2000; Kelley et al., 2002, 2004; Robbins and Everitt, 2002; Berridge, 2003; Koob, 2003; Bodnar et al., 2005; Kalivas and Volkow, 2005).”