Stress, dysregulation of drug reward pathways, and the transition to drug dependence.

By G. Koob, M. Kreek. American Journal of Psychiatry, 2007

879 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/97dbf627a0a1134269d01b78e846f84ed4d8f3d9

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In Behavioral Neuroscience

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Citations in the corpus

Neurocircuitry of Addiction (2009, background): “…by corticotropin-releasing factor (CRF) are activated during withdrawal from chronic administration of all major drugs with abuse potential, with a common response of elevated adrenocorticotropic hormone, corticosterone, and amygdala CRF during acute withdrawal (Koob, 2008; Koob and Kreek, 2007).”
Neural Regulation of Endocrine and Autonomic Stress Responses (2009, background): “In particular, drugs of abuse elicit strong unconditioned and conditioned activation of the HPA axis and ANS that are linked to the addiction proces”
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System (2008, background): “Sustained stressful experience can induce despair and increase the risk of clinical depression and drug abuse (Gold and Chrousos, 2002; Volkow and Li, 2004; Fox et al., 2007; Koob and Kreek, 2007).”
The glutamate homeostasis hypothesis of addiction (2009, background): “Third, even if one considers only cocaine self-administration and reinstatement, other differences between experimental protocols — such as the extent of total drug intake, the number of days of training or withdrawal, and the presence or absence of extinction training — might affect the presence or”
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. (2007, positive): “Since behavioral responses to drugs of abuse and stress are closely linked (Koob and Kreek, 2007), effects mediated in part by the NAc (Nestler and Carlezon, 2006), we determined whether HDAC5 plays an analogous role in an animal's adaptation to chronic stress.”
Depression, Anxiety and Stress during COVID-19: Associations with Changes in Physical Activity, Sleep, Tobacco and Alcohol Use in Australian Adults (2020, background): “Harmful intake of alcohol leads to neuroadaptations that exacerbate alcohol cravings during times of stress [12].”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “Another important topic is how stress systems interact with brain reward systems [151] [152] [153] [154] [155].”
Reward Processing by the Opioid System in the Brain (2009, positive): “Together, these structures form the extended amygdala (6, 61, 97), which plays a key role in reinforcement (196, 198, 201, 334, 399).”
A role for brain stress systems in addiction. (2008, positive): “With repeated administration of cocaine, opiates, nicotine, and alcohol, these acute changes are blunted or dysregulated (Kreek and Koob, 1998; Rasmussen et al., 2000; Goeders, 2002; Koob and Kreek, 2007; Sharp and Matta, 1993; Semba et al., 2004).”
The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. (2010, positive): “…mechanism of stress, has been postulated to produce an aversive state that indirectly increases intake, by promoting the eating of highly palatable food (comfort food) in order to reduce the aversive state (hedonic self-medication) (Dallman et al., 2003; Dallman et al., 2006; Koob and Kreek, 2007).”