Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

By G. Harrigan, Royston Goodacre. Springer US, 2003

371 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aaa8d182eb10071e60d7059b923796f3a326b64b

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In Molecular Biology

Citations in the corpus

Targeted Metabolomics (2012, background): “…terminal downstream product of the genome and consists of the total complement of all the low-molecular-weight molecules (metabolites) in a cell, tissue, or organism required for growth, maintenance, or normal function in a specific physiological state (Goodacre, 2003; Goodacre et al., 2004; Fig.”
Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS. (2005, background): “The emerging field of metabolomics requires profiling and fingerprinting methods (Fiehn et al., 2000a; Glassbrook and Ryals, 2001; Harrigan and Goodacre, 2003; Sumner et al., 2003) capable of measuring the absolute or relative amounts of all metabolites (the metabolome).”
Decoupling dynamical systems for pathway identification from metabolic profiles (2004, background): “At present, metabolic profiles are typically obtained as snapshots of many metabolites at one time point or as time series measurements of a limited number of metabolites (Goodacre and Harrigan, 2003).”
Metabolomics: a global biochemical approach to drug response and disease. (2008, methodology): “Many names have been used to refer to this new field, including metabonomics, metabolic profiling, metabolic fingerprinting, and metanomics, among others (3, 17).”
Metabolomics: Current analytical platforms and methodologies (2005, methodology): “In metabolomics, GC-MS has been described as the gold standard ([ 1 ], chapter 11), although it is biased against non-volatile, high-MW metabolites.”