Metabolomics: Current analytical platforms and methodologies

By Warwick B. Dunn, David I. Ellis. 2005

1,139 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/98d2c27620d295c296789133ef95419d8093e2c2

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In Spectroscopy

Citations in the corpus

Multivariate Analysis in Metabolomics. (2012, background): “The number of smallmolecule metabolites in a biofluid, cell lysate, tissues or organ differs wildly depending on the organism studied, ranging from several hundred to hundreds of thousands [18].”
Visualization of omics data for systems biology (2010, methodology): “Metabolic profile data A wide variety of spectroscopic methods are being used for high-throughput studies of small-molecule metabolite”
Metabolomics and fish nutrition: a review in the context of sustainable feed development (2018, background): “Two common metabolomic approaches can be used to extract pertinent information from biological systems: fingerprinting and profiling usually using NMR and MS (Goodacre et al. 2004; Dunn 2005).”
CFM-ID: a web server for annotation, spectrum prediction and metabolite identification from tandem mass spectra (2014, methodology): “Electrospray tandem mass spectrometry (ESI-MS / MS) is a widely used technique in untargeted metabolomics experiments (3–6).”
Review of recent developments in GC–MS approaches to metabolomics-based research (2018, methodology): “In modern times APCI sources are typically coupled to high mass resolution systems including time-of-flight (TOF) and Fourier transform (FT) orbitrap and ion cyclotron resonance (ICR) systems.”
Metabolomics of aquatic organisms: the new omics on the block (2007, methodology): “A comparison of these techniques is beyond the scope of this commentary, so readers are referred to articles by Dunn & Ellis (2005), Pelczer (2005), and Villas-Boas et al. (2005).”
Competitive fragmentation modeling of ESI-MS/MS spectra for putative metabolite identification (2013, methodology): “Liquid chromatography combined with electrospray ionisation mass spectrometry (ESI-MS) is one of the most frequently used approaches for conducting metabolomics experiments (Dunn and Ellis 2005; Tautenhahn et al. 2012; Kind and Fiehn 2010; Wishart 2011).”
Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst (2011, methodology): “This growth has also been aided by advances in analytical technologies, such as high-resolution nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS) and various compound separation technique”
Metabolic fingerprinting as a diagnostic tool. (2007, methodology): “Urology 65(6), 1126–1130 (2005). • In vitro proof of concept experiment that illustrates that in vivo Raman spectroscopy using fibre optic laser delivery and collection of Raman scattered light is possible.”
A tutorial review: Metabolomics and partial least squares-discriminant analysis--a marriage of convenience or a shotgun wedding. (2015, methodology): “Table 1 describes the advantages and disadvantages of some of the most common analytical techniques used in metabolomics approaches; for a more detailed discussion on instrumentation and their applications the reader is directed to the following papers [46,49,62–65].”