The P2X7 Receptor: A Key Player in IL-1 Processing and Release1
By D. Ferrari, C. Pizzirani, E. Adinolfi, R. Lemoli, A. Curti, M. Idzko, E. Panther, F. Di Virgilio. Journal of Immunology, 2006
885 citations recorded by the source corpus.
Subfields: Immunology, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/77c4409d780c0976e5243d43f6fc0953ed1cd291
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Citations in the corpus
- Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor (2006, background): “…only known physiological stimuli for this rapid processing and release of bioactive IL-1b are allogenic cytotoxic T cells and activation of the ATP-gated P2X7 receptor (P2X7R) (Perregaux and Gabel, 1994; Perregaux et al, 1996; Mackenzie et al, 2001; Kahlenberg and Dubyak 2004; Ferrari et al, 2006).”
- Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). (2009, background): “Instead, NLRP3 mutations may function independently of exogenous ATP due to heightened downstream sensitivity to the effect of ATP on the P2X7 receptor at the cell surface, which is a well-documented stimulus for the processing and secretion of IL-1β (48, 49).”
- Vitamin D: modulator of the immune system. (2010, neutral): “Addition of the active peptide, which is cleaved from cathelicidin, could specifically counteract mycobacterial growth in culture [26].”