Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review

By Marc Laruelle. Journal of Cerebral Blood Flow and Metabolism, 2000

992 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/aa9bb874a8e6b1f87b41389338cb8d78d2283c14

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, positive): “The released dopamine competes with the radioligand and leads to a reduction in radiotracer binding and is considered to be an indirect index of released dopamine.(26,27) All the studies using this approach have found evidence of roughly doubled radiotracer displacement in patients with schizophreni”
Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum (2003, background): “other phenomena, such as receptor internalization or polymerization, have also been implicated (Laruelle, 2000; Logan et al., 2001).”
Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [11C]Raclopride (2004, background): “There is considerable evidence that manipulations that lead to an increase in synaptic dopamine in the striatum are associated with proportional reductions in binding of this tracer (Breier et al., 1997; Endres et al., 1997; Hartvig et al., 1997; Laruelle et al., 1997; Laruelle, 2000).”
Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. (2003, background): “There is considerable evidence that in vivo binding of benzamide tracers such as [11C]raclopride is inversely proportional to levels of synaptic dopamine at the time of the scan (Dewey et al., 1993; Breier et al., 1997; Endres et al., 1997; Hartvig et al., 1997; Laruelle et al., 1997; Laruelle, 2000”
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. (2001, background): “…binding following administration of pharmacologic agents that increase extracellular [DA] does not appear solely explained by competition between radioligand and endogenous DA for DA D2/D3 receptors and may also involve agonist-mediated internalization of DA D2/D3 receptors (Laruelle 2000).”
Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands (2007, background): “Although the result of complex conditions, in vivo radioligand binding can sometimes monitor important parameters like competition with the endogenous transmitter (Laruelle, 2000).”
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers (2003, background): “It is thought that the reduction in [ 11 C]raclopride binding that occurs following dopamine release is due to internalization of D2 receptors (Laruelle, 2000; Sun et al., 2003), an effect that lasts considerably longer than the increase in synaptic dopamine levels.”
Prefrontal Dopamine D1 Receptors and Working Memory in Schizophrenia (2002, background): “…binding of [ 3H]SCH 23390 (Guo et al., 2000), an effect that might be attributable to receptor translocation from the endosomial compartment to the cell surface and lower in vivo affinity of SCH 23390 for externalized compared with internalized receptors (Dumartin et al., 2000; Laruelle, 2000).”
Positron Emission Tomography (2020, neutral): “However, the assumptions break down in both the SPECT and PET cases when more complex objects are studied, such as the thorax [37, 51, 52].”