Prefrontal Dopamine D1 Receptors and Working Memory in Schizophrenia

By Anissa Abi-Dargham, O. Mawlawi, I. Lombardo, R. Gil, D. Martínez, Yiyun Huang, D. Hwang, J. Keilp, L. Kochan, R. V. Van Heertum and 2 more. Journal of Neuroscience, 2002

765 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/b97341584fe192f4594cc52753320eb99d957365

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Citations in the corpus

Computational models of schizophrenia and dopamine modulation in the prefrontal cortex (2008, background): “It was further hypothesized 68 , on the basis of a post-mortem investigation 122 , experimental evidence 123–125 and association studies of the catechol-O -methyl- transferase ( COMT ) gene (for example, see REF.”
The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, neutral): “One reported reduced D1 receptor density(41) another no difference from controls,(42) and a further study using a different radiotracer reported increased D1 levels.(51) This variation may be explained by different properties”
Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, result): “One study of antipsychotic-naïve patients and one of naïve and previously treated patients showed increased densities of D1 receptors in the prefrontal cortex in patients (Abi-Dargham et al., 2002, 2012).”
Hierarchical Error Representation: A Computational Model of Anterior Cingulate and Dorsolateral Prefrontal Cortex (2015, background): “Dysfunction of the DA system is implicated in a range of behavioral pathologies, including obsessive-compulsive disorder and schizophrenia (Abi-Dargham et al., 2002; Cohen & Servan-Schreiber, 1993; Denys, Zohar, & Westenberg, 2003; Goodman et al., 1990).”
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. (2004, result): “Consistent with these findings, Abi-Dargham et al. [ 37 ] reported that using positron emission tomography (PET) and a specific dopamine D1 receptor radiotracer, schizophrenic patients tended to show higher receptor availability than controls, particularly in DLPFC.”
Dysfunction of ventral striatal reward prediction in schizophrenia (2006, background): “…dysfunction in prefrontal – striatal – thalamic neurocircuits (Andreasen et al., 1996; Callicott et al., 2000; Meyer-Lindenberg et al., 2002, 2005; Abi-Dargham et al., 2002; Molina et al., 2003), only a few imaging studies have examined the central correlates of negative symptoms associated…”
The principal features and mechanisms of dopamine modulation in the prefrontal cortex. (2004, background): “Accordingly, recent data shows that D1 receptor density in PFC is directly correlated to the severity of negative symptoms in schizophrenia (Abi-Dargham et al., 2002; Abi-Dargham and Moore, 2003; Guo et al., 2003).”