Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria.

By Wayne C. Drevets, Clara Gautier, J. Price, David J. Kupfer, Paul Kinahan, Anthony A. Grace, Joseph L. Price, C. Mathis. Biological Psychiatry, 2001

723 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/79601de67628ab3636a465f76f94271e9b5061a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Neurology

Citations in the corpus

Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study (2011, background): “In functional magnetic resonance imaging (fMRI) studies, the VS responds to drugs (Breiter et al., 1997; Drevets et al., 2001), attractive faces (Senior, 2003), erotic images (Sabatinelli et al.”
Beautiful faces have variable reward value: fMRI and behavioral evidence. (2001, methodology): “…the region of interest conventions described previously (Breiter et al., 1997) for the NAc, SLEA, amygdala, Data Analysis hypothalamus, VT, and GOb (BA 11/47) (Breiter et al., 2001), and Transformation of fMRI BOLD Data before the ventral striatum proximate to the NAc (Drevets et al., 2001).”
A common neurobiology for pain and pleasure (2008, background): “Dopamine, motivation and analgesia Considering the close association that exists between motivation, learning and hedonic feelings, it is not surprising that dopamine signalling has been consistently reported to correlate with stimulus reward valu”
A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. (2005, background): “And the degree of amphetamine-induced DA release in healthy human ventral striatum assessed by PET was correlated strongly with feelings of euphoria (Drevets et al. 2001).”
Addiction: Beyond dopamine reward circuitry (2011, background): “In humans, PET studies have shown that several drugs [stimulants (7, 8), nicotine (9), alcohol (10), and marijuana (11)] increase DA in dorsal and ventral striatum (where NAc is located).”
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications (2004, background): “19 Intravenous amphetamine also increases DA in human brain and these increases have also been shown to be associated with the subjective perception of reinforcement”
The Reward Circuit: Linking Primate Anatomy and Human Imaging (2010, methodology): “…entire region has been a focus for the study of reinforcement and the transition between drug use for a reward and as a habit (Bowman et al , 1996; Drevets et al , 2001; Jensen et al , 2003; Kalivas et al , 2005; Lyons et al , 1996; Parkinson et al , 2000; Schultz et al , 1992; Taha and Fields,…”
The neurobiology of positive emotions. (2006, background): “…dopamine activity in the sum, the evidence is substantial for a sub-neocortical locus of control for the generation of experienced affects that accompany various emotional states and consummatory responses. ventral striatum (Drevets et al., 2001; Martinez et al., 2003; Volkow and Swanson, 2003) 2.”
Imaging dopamine's role in drug abuse and addiction. (2009, neutral): “-PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript descriptors of reward (high, euphoria) ( Volkow et al., 1996a; Drevets et al., 2001).”
Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding (2011, background): “Pavlovian interference likely contributes to many quirks of behaviour such as impulsivity [12], framing and [13], endowment effects [14] and many other ‘‘anomalies’’ [15], including neurological [16–19] and psychiatric diseases [20–26].”
Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “These data suggest that despite apparent correlations between stimulant-induced DA release and subjective euphoria (Drevets et al., 2001), this result is mediated by downstream effects on opioid function, and is unlikely to be a direct consequence of increased extracellular DA (Volkow et al., 1996).”
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens (2001, background): “In addition, PET studies have demonstrated positive correlations between stimulant-induced dopamine release in the ventral striatum and ratings of euphoria in humans (Volkow et al., 1999; Drevets et al., 2001).”
Neurobiology of emotion perception I: The neural basis of normal emotion perception. (2003, background): “…response to dextroamphetamine and the magnitude of dopamine release in anteroventral striatal areas, indicating that the dopamine signal in these regions may be important for the formation of associations between salient contextual stimuli and internal rewarding events (Drevets et al 2001 ).”