Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.

By Sanjay Kumar, I. Maxwell, A. Heisterkamp, Tom Polte, T. Lele, M. Salanga, E. Mazur, Donald E. Ingber. Biophysical Journal, 2006

714 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/464a1f6d25e3856ce629c40de63028d7b53d8bb6

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In Biomedical Engineering

In Cell Biology

In Orthopedics and Sports Medicine

Citations in the corpus

Environmental sensing through focal adhesions (2009, background): “The presence of myosin II is responsible for the contractile nature of the stress fibre”
Balancing forces: architectural control of mechanotransduction (2011, positive): “On the single-cell level, the ablation of even a single actin fibre is able to induce a change in cell shape, alter cytoskeletal organization and modify focal adhesion assembl”
Physics of adherent cells (2013, background): “Laser cutting experiments demonstrated that stress fibers are under large tension, since they retract over large distances when being cut (Colombelli et al., 2009; Kumar et al., 2006).”
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells (2009, methodology): “To test the hypothesis that ECM rigidity influences the behavior of cultured glioma cells, we fabricated a series of fibronectin-coated polyacrylamide ECMs of variable stiffness as we and others have done previously (15,30,31).”
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus (2009, background): “) This model takes into account the observation that individual cytoskeletal filaments can bear significant tensile and compressive loads in living cells because their structural integrity is maintained for longer than the turnover time of individual protein monomer”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “…smaller-scale dynamics that are suggestive of their sarcomeric organization: Distances between α-actinin bands decrease under conditions that allow or promote contraction and increase under stretching or relaxation conditions (Colombelli et al. 2009, Kumar et al. 2006, Peterson et al. 2004).”
Mechanics, malignancy, and metastasis: The force journey of a tumor cell (2009, methodology): “In the context of understanding biophysical signaling between capillary endothelial cells and the ECM in tumor angiogenesis [112], SLA has been employed to probe the micromechanical properties of actomyosin stress fiber bundles (stress fibers), which are the contractile structures that anchor and en”
A tense situation: forcing tumour progression (2009, background): “For instance, cells on stiff substrates tolerate excision of a single stress fibre by exerting greater myosin-dependent force, whereas the same manipulation in cells grown on a compliant substrate disrupts the cellular force balance and cell shap”