Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial.

By E. Lonn, J. Bosch, S. Yusuf, P. Sheridan, Janice Pogue, J. Arnold, C. Ross, A. Arnold, P. Sleight, J. Probstfield and 1 more. Journal of the American Medical Association (JAMA), 2005

1,212 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aa7f6fdea5559fb6b05387544350716567fcc533

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. G. Hansson
2. Peter Libby
3. Michael Ristow

In Cancer Research

1. Peter Libby
2. G. Hansson
3. Michael Ristow
4. P. Ridker

In Molecular Biology

1. Peter Libby
2. P. Ridker
3. G. Hansson
4. E. Murphy
5. Michael Ristow
6. C. Steenbergen

Citations in the corpus

• Progress and challenges in translating the biology of atherosclerosis (2011, methodology): “Well-powered randomized clinical trials have consistently shown that antioxidant vitamins, such as vitamins E and C, do not reduce cardiovascular events over the timescale and doses studie”
• Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, critical): “However, despite this, vitamin E did not improve cardiovascular outcomes in a large multicenter trial and actually increased congestive heart failure (201).”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “For example, vitamin E was associated with heart failure in patients with vascular disease or diabetes mellitus in the Heart Outcomes Prevention Evaluation Study (Lonn et al., 2005) and increased prostate cancer after 7 years in the Selenium and Vitamin E Cancer Prevention Trial (Klein et al., 2011)”
• Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. (2008, result): “[45] Lonn, E.”
• American Cancer Society guidelines on nutrition and physical activity for cancer prevention (2002, methodology): “Heart failure rates were actually higher among those taking vitamin E supplements.(376) Vitamin E supplementation is not recommended for the prevention of cancer or chronic diseases, although foods containing vitamin E, including nuts and some unsaturated oils, can be healthy and have been demonstra”
• How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis). (2010, background): “Accordingly, other studies show that antioxidant supplements may be disease-promoting and/or may even reduce lifespan in humans (Albanes et al., 1996; Omenn et al., 1996; Vivekananthan et al., 2003; Lonn et al., 2005; Bjelakovic et al., 2007; Ward et al., 2007; Lippman et al., 2009).”