Progress and challenges in translating the biology of atherosclerosis

By Peter Libby, P. Ridker, G. Hansson. Nature, 2011

3,873 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/31a83a618339a5f25357342f3633f5a423880eb6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Peter Libby
2. P. Ridker
3. I. Tabas
4. K. Bornfeldt
5. G. Hansson
6. Jongsoon Lee
7. A. Lichtman
8. Byung-Cheol Lee

In Immunology

1. Peter Libby
2. I. Tabas
3. A. Lichtman
4. P. Ridker
5. K. Bornfeldt
6. G. Hansson
7. Jongsoon Lee
8. Byung-Cheol Lee

In Surgery

1. Peter Libby
2. I. Tabas
3. K. Bornfeldt
4. G. Hansson
5. Jongsoon Lee
6. A. Lichtman
7. Byung-Cheol Lee
8. A. Tall

Citations in the corpus

• NF-κB signaling in inflammation (2017, neutral): “126 The pathogenesis of atherosclerosis involves different cell types, including endothelial cells, monocytes and T cells.”
• The health effects of ambient PM2.5 and potential mechanisms. (2016, background): “Both inflammation and endothelial dysfunction are considered to be the important mechanisms to trigger AS (Libby et al., 2011).”
• Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans (2013, background): “In particular, the pentraxin C-reactive protein (CRP), an acute phase reactant, has proven particularly useful as a biomarker of inflammation in clinical studies (Libby et al., 2011).”
• History of Discovery: Inflammation in Atherosclerosis (2012, background): “The simplistic dichotomization of macrophages into categories based on certain markers may have heuristic value, but applies more to mice than to humans, and glosses over overlapping patterns of activation that characterize complex chronic inflammatory processes in humans, such as atherosclerosis.(3”
• CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis (2016, background): “Atherosclerosis is characterized by the accumulation of diseased macrophages and vascular smooth muscle cells (SMCs), which not only encroach on the lumen of the associated vessel but may also undergo programmed cell death 1,12 .”
• Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. (2014, neutral): “Atherosclerosis 2009 Jul;205(1):302-308.”
• Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes – Mechanisms, Management, and Clinical Considerations (2016, neutral): “Role of Vascular Calcification Individuals with diabetes mellitus are more likely to have calcified atherosclerotic lesions(166) which occur in more advanced, complex atherosclerotic lesions.(167) Coronary calcium score as measured by electron-beam computed tomography is an independent risk factor f”
• Research Progress on the Relationship between Atherosclerosis and Inflammation (2018, background): “Atherosclerosis is usually considered a chronic inflammatory disease [1] as inflammation plays an important role in all stages of the atherosclerotic process [2].”
• Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, positive): “Endothelium is both the largest distributed organ in the human body (with an aggregate mass comparable with other vital organs such as the kidney), and an integral part, anatomically and functionally, of each of the body’s composite tissues and organs.227 As we have considered in detail in this revi”
• AMPK, insulin resistance, and the metabolic syndrome. (2013, positive): “Likewise, statins have been shown to activate AMPK and increase NO synthesis in HUVECs and in whole aorta in mice (98), effects that may contribute to their antiatherosclerotic action not accounted for by cholesterol lowering (98, 99).”
• A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins (2015, neutral): “The foam cells secrete a variety of cytokines, thereby initiating an inflammatory reaction (Hansson and Jonasson, 2009; Libby et al., 2011).”