Viral subversion of the immune system.

By D. Tortorella, B. Gewurz, Margo H. Furman, D. Schust, Hidde L. Ploegh. Annual Review of Immunology, 2000

899 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/aa4811c031ceaa6170164480040bce8ad1723020

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Animal Science and Zoology

1. A. Alcamí
2. R. Khanna
3. M. Barry
4. R. Bleackley

In Epidemiology

1. S. Lecker
2. W. Mitch
3. A. Alcamí
4. R. Khanna
5. A. Goldberg
6. R. Steinman
7. E. Latz
8. T. Crough

Citations in the corpus

• Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. (2006, background): “Although the great majority of peptides that are generated by the proteasome during breakdown of intracellular proteins are digested rapidly to free amino acids (49,55), some escape this fate and are transported into the ER.”
• Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire1 (2001, background): “Although CD56(1) lymphocytes are derived from multiple lineages, they share a functional association with immunosurveillance and antitumor responses (1, 21, 22).”
• Immunobiology of Human Cytomegalovirus: from Bench to Bedside (2009, methodology): “Comprehensive details of these strategies were provided in previous reviews (15, 177, 269, 274), but they are summarized below.”
• Immune functions encoded by the natural killer gene complex (2003, background): “Interestingly, expression of NKG2D ligands is also induced after virus infection, allowing co-stimulation of virus-specific cytotoxic T lymphocytes (CTLs) and efficient killing of infected cells, even when the virus has markedly downregulated expression of MHC class I molecules and, therefore, antig”
• The Complement System (2010, background): “Similarly, complement-inhibiting proteins expressed by viruses such as vaccinia, cowpox and smallpox block C3 convertase formation (for a review see (Tortorella et al. 2000).”
• Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “At least four gene products interfere with major histocompatibility complex class I antigen presentation (16, 58), and two CMV-encoded proteins interact with HLA-E, which leads to suppression of NK responses and protection from NK-mediated lysis (12, 54, 57).”
• Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells (2002, background): “The Herpesviruses, especially HSV and CMV, encode gene products that interfere with MHC class I antigen presentation escaping T cell surveillance (49).”