Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.

By S. Lecker, A. Goldberg, W. Mitch. Journal of the American Society of Nephrology, 2006

1,185 citations recorded by the source corpus.

Subfields: Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/aa07535d801943dbf7c58970ff057d21ad52934a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Sandri
2. P. Bonaldo
3. A. Goldberg

In Pulmonary and Respiratory Medicine

1. M. Sandri
2. P. Bonaldo

Citations in the corpus

• Cellular and molecular mechanisms of muscle atrophy (2013, positive): “The increase in muscle mass caused by loss of myostatin is a consequence of both hyperplasia (i.e. increased cell number) and hypertrophy (i.e. increased cell size) (Lee, 2004; Lee and McPherron, 1999; McPherron et al., 1997).”
• Mitochondrial fission and remodelling contributes to muscle atrophy (2010, background): “For instance, amino acids generated from muscle protein breakdown are used by the liver to produce glucose and to support acute phase protein synthesis (Lecker et al, 2006).”
• FoxO3 controls autophagy in skeletal muscle in vivo. (2007, background): “In the first, target proteins are conjugated to multiple ubiquitin moieties and ubiquitin-tagged proteins are degraded within the proteasome complex (Lecker et al., 2006).”
• FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. (2007, background): “It occurs in specific muscles with inactivity and denervation and systematically in fasting and many diseases, including cancer, diabetes, sepsis, and renal failure (Kandarian and Jackman, 2006; Lecker et al., 2006).”
• Autophagy is required to maintain muscle mass. (2009, positive): “For instance, amino acids generated from muscle protein breakdown are utilized by the liver to produce glucose and to support acute phase protein synthesis (Lecker et al., 2006).”
• What determines growth potential and juvenile quality of farmed fish species (2013, background): “The ubiquitin-proteasome system plays a pivotal role in the degradation of short-lived and regulatory proteins important in a variety of basic cellular processes, including the rapid removal of proteins, regulation of gene transcription, functioning of the immune system, and as a source of amino aci”