BMP4 initiates human embryonic stem cell differentiation to trophoblast

By R. Xu, Xin Chen, D. Li, Rui Li, Gregory C. Addicks, Clay Glennon, T. Zwaka, James A. Thomson. Nature Biotechnology, 2002

1,167 citations recorded by the source corpus.

Subfields: Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/aa2d0c6728f91d895b08cf1c1f58611fb7f02dc7

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In Molecular Biology

1. G. Keller
2. L. Vallier
3. Kenneth R. Boheler
4. A. Wobus
5. R. Pedersen
6. Morgan Alexander
7. Feras Hatahet
8. N. Xu

In Public Health, Environmental and Occupational Health

1. G. Keller

Citations in the corpus

• Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E.coli (2011, background): “BMP4 is a cytokine that regulates the formation of teeth, limbs and bones it plays a role in fracture repair and it initiates human stem cell differentiation to trophoblasts [26].”
• MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (2009, positive): “To address the specificity of the OCT4 interaction on the promoter, we tested whether the OCT4-bound DNA would be depleted when the OCT4 level is reduced in differentiating hESCs induced by BMP4 (‘‘hESCBMP4’’) (Xu et al., 2002).”
• Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “hES cells differ from mouse cells in this respect, as when induced with BMP4, they will give rise to cells that display characteristics of the trophoblast lineage (Xu et al. 2002).”
• TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells (2005, background): “As previously reported (Xu et al., 2002), these conditions resulted in a decrease in OCT3/4 levels and a concomitant change in morphology Fig.”
• Efficient differentiation of human embryonic stem cells to definitive endoderm (2005, background): “Application of BMP4 to hES cells results in differentiation to trophectoder”
• Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, background): “Likewise, whereas BMP4 has been shown to block differentiation of mESCs along the neuroectoderm default pathway (Ying et al., 2003), it induces trophectoderm differentiation of hESCs (Gerami-Naini et al., 2004; Xu et al., 2002).”
• Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. (2004, background): “of syncytial trophoblast markers, the cells do not continue to divide (59).”
• Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells (2005, background): “We have previously shown that the addition of BMPs to hESCs cultured in CM containing bFGF promotes trophoblast differentiatio”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “Interestingly, BMP-4 induced hES cells to develop into extraembryonic, trophoblast-like cells (403), a property clearly different from mES cells.”
• Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling (2009, background): “, suppression of BMP-induced differentiation toward trophoblast lineag”