Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
By R. Xu, Ruthann M Peck, D. Li, Xuezhu Feng, T. Ludwig, James A. Thomson. Nature Methods, 2005
1,060 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3f9497b8216f4acf331804a2f4b584066b1ab094
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In Biomedical Engineering
In Molecular Biology
- S. Yamanaka
- Austin G Smith
- José C. R. Silva
- Kazutoshi Takahashi
- K. Hochedlinger
- T. Ichisaka
- Qi-Long Ying
- L. Vallier
Citations in the corpus
- Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “BMP induces differentiation in hES cells (Xu et al., 2005) but is involved in self renewal of mouse ES cells (Ying et al.”
- Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. (2008, background): “Because BMPs also regulate regeneration of mature tissues and stem cell differentiatio”
- Heparan sulfate proteoglycans. (2011, background): “For example, syndecan-1 shedding modulates chemokine-dependent inflammatory processes in models of tissue damage caused by noninfectious agents (Li et al. 2002; Xu et al. 2005b; Hayashida et al. 2009b).”
- Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, methodology): “…for a role of FGF in hESC self-renewal (Amit et al., 2000; Amit et al., 2004; James et al., 2005; Schuldiner et al., 2000; Wang et al., 2005b; Xu et al., 2005a; Xu et al., 2005b), this has all been obtained in complex culture conditions, in which other contributory factors could play…”
- Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “The mechanism by which bFGF exert its functions is incompletely known, although one of the effects is suppression of BMP signalling that would otherwise induce differentiation (Xu et al., 2005).”
- Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, neutral): “pathway [20–22].”
- Capture of authentic embryonic stem cells from rat blastocysts. (2008, positive): “In this respect they resemble primate embryo-derived stem cells (Thomson et al., 1998; Vallier et al., 2005; Xu et al., 2005).”