Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors

By E. Butelli, L. Titta, M. Giorgio, H. Mock, A. Matros, Silke Peterek, E. Schijlen, R. Hall, A. Bovy, Jie Luo and 1 more. Nature Biotechnology, 2008

1,151 citations recorded by the source corpus.

Subfields: Biochemistry, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/aa192dfb49e04eacdd8f99ec16d1909ca1984357

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Citations in the corpus

A Commercial Extract of Brown Macroalga (Ascophyllum nodosum) Affects Yield and the Nutritional Quality of Spinach In Vitro (2013, background): “1999) and enhancing anthocyanins in tomato (Butelli et al. 2008).”
An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae (2010, background): “Recently, research on anthocyanins has intensified because of their potential benefits to human health, including protection against cancer, inflammation, coronary heart diseases and other age-related diseases [6-11].”
Retrotransposons Control Fruit-Specific, Cold-Dependent Accumulation of Anthocyanins in Blood Oranges[W][OA] (2012, background): “A regulatory complex, composed of proteins of the Myb, basic helix-loop-helix (bHLH), and WD-repeat families of transcription factors, governs the expression of the structural genes required for anthocyanin biosynthesis, modification, and transport (Ramsay and Glover, 2005; Butelli et al., 2008).”
Response of Plant Secondary Metabolites to Environmental Factors (2018, background): “Over-expression of AmDEL gene from Antirrhinum majus, resulting in both peel and flesh of fruit with intense purple colouration, significantly increased flavonoids accumulation [94].”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “Numerous laborato y and epidemiological st dies suggest a beneficial effect of flavonoids f r human health, pr venting the occurrence of hronic age-relate diseases such as cardiovascular diseases or certain cancers (Espin et al., 2007; Butelli et al., 2008; Luceri et al., 2008).”
The bHLH transcription factor MdbHLH3 promotes anthocyanin accumulation and fruit colouration in response to low temperature in apples. (2012, background): “Furthermore, locus mutation and genetic manipulation of bHLH and MYB genes have produced an increasing number of red or purple staple, fruit and ornamental crops that are rich in anthocyanins, which provide enhanced health benefits for consumers and unprecedented aesthetics (Escribano-Bailón, Santos”
The role of flavonoids in root-rhizosphere signalling: opportunities and challenges for improving plant-microbe interactions. (2012, background): “For example, it has been shown that ectopic expression of MYB transcription factors can significantly increase anthocyanin synthesis in tomato (Butelli et al., 2008).”
The flavonoid biosynthetic pathway in Arabidopsis: structural and genetic diversity. (2013, positive): “Biotechnological application by transgenic technology for the promotion of human health by engineering of flavonoid is based on an in-depth understanding of fundamental mechanism of the biosynthetic mechanisms is also a promising area for future research [164,165].”
Flavonoids: biosynthesis, biological functions, and biotechnological applications (2012, background): “For example, the co-expression of the Delila (Del) and Rosea1 (Ros1) cDNAs, each under the control of the fruit-specific E8 promoter, led to high levels of anthocyanin throughout the fruit tissues, which were consequently purple colored (Butelli et al., 2008).”
Tomato (Solanum lycopersicum L.) in the service of biotechnology (2015, background): “Similar studies were conducted by Butelli et al. (2008) and Orzaez et al. (2009) on tomato line (cv. MicroTom) expressing Delia and Rosea1 TFs under the control E8 promoter (tomato fruit-specific E8 promote) where the fruit displayed the purple-fruited phenotype.”
Rewiring of the Fruit Metabolome in Tomato Breeding. (2018, background): “These metabolites not only play important roles in plant growth, development, and adaptation to environmental changes but also are important sources of human food, medicine, and energy (Butelli et al., 2008; Chen et al., 2016).”
Anthocyanin Biosynthesis and Degradation Mechanisms in Solanaceous Vegetables: A Review (2018, background): “Consumption of transgenic anthocyanin-rich tomatoes led to a 25% extension of the lifespan of the p53 mouse, a cancer mouse model (Butelli et al., 2008), and a reduction in the development of atherosclerosis in a cardiovascular disease mouse model (Gonzali et al.”