Autophagy is required to maintain muscle mass.

By E. Masiero, L. Agatea, C. Mammucari, B. Blaauw, E. Loro, M. Komatsu, D. Metzger, Carlo Reggiani, S. Schiaffino, M. Sandri. Cell Metabolism, 2009

1,238 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/96547e2746ac012680e070ad6525745851f5c232

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Molecular Biology

In Neurology

Citations in the corpus

Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “To overcome this concern, inducible knockout systems might be useful.(171,315) One additional caveat to knockdown experiments is that pathogen-associated molecular pattern (PAMP) recognition pathways can be triggered by doublestranded RNAs (dsRNA), like siRNA probes, or the viral vector systems that”
Cellular and molecular mechanisms of muscle atrophy (2013, neutral): “Therefore, activated Smads must associate with different DNA-binding cofactors for the recognition and regulation of specific target genes (Massagué et al., 2005).”
Autophagy: Renovation of Cells and Tissues (2011, background): “, 2008) or Atg7 (Masiero et al., 2009) disrupted specifically in the skeletal muscle display age-dependent muscle atrophy.”
Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy (2020, background): “In addition, skeletal muscle-specific knockout mice for Atg7, which acts as an E1-like enzyme critical for autophagy regulation, showed profound muscle atrophy and age-dependent decline in muscle force [59].”
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis (2011, background): “However, although these mechanisms have been linked mainly to muscle atrophy, it is now emerging that autophagy has an important role not only under the extreme conditions of atrophic muscle remodelling but also in muscle maintenance, by removing defective organelles and contributing to energy homeo”
Clinical review: intensive care unit acquired weakness (2015, background): “Autophagy, which is a cellular housekeeping system that mediates removal of damaged large organelles and protein aggregates, is an important factor in maintaining muscle fiber integrity [36], and deficient autophagy may have a crucial role in the development of ICUAW [35].”
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, background): “, 2007) and in the preservation of muscle sarcomere organization (Arndt et al., 2010; Masiero et al., 2009), highlighting the importance of fine-tuning the degree of activation of stress resistance pathways to maintain muscle homeostasis.”
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “cytoplasmic proteins and organelles in response to starvation have been associated with premature aging and age-related disorders (Hara et al., 2006; Komatsu et al., 2006; Jung et al., 2008; Pickford et al., 2008; Masiero et al., 2009; Lee et al., 2010).”