Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.

By R. Salcedo, M. Ponce, H. Young, K. Wasserman, Jerrold M. Ward, H. Kleinman, J. Oppenheim, W. Murphy. Blood, 2000

868 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a9d678992d9840767092710f5ab6a295f15b17fa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology and Allergy

1. Christopher S. Chen
2. Michael T. Yang
3. Peter A. Galie
4. Colin K. Choi
5. Susie S. Cha
6. J. Cyster
7. Sarah C. Stapleton
8. Duc-Huy T. Nguyen

In Molecular Biology

1. Christopher S. Chen
2. A. Richmond
3. Michael T. Yang
4. Dingzhi Wang
5. Peter A. Galie
6. Colin K. Choi
7. Susie S. Cha
8. J. Cyster

In Oncology

1. J. Cyster
2. A. Ben-Baruch
3. A. Richmond
4. D. Raman
5. Y. Thu
6. G. Soria
7. P. Baugher

Citations in the corpus

• Eicosanoids and cancer (2010, background): “by directly recruiting endothelial cells that express its receptor CCR2 in vitro and in vivo”
• Chemokines in cutaneous wound healing (2001, neutral): “Basically, Salcedo and colleagues [67] came to”
• The inflammatory chemokines CCL2 and CCL5 in breast cancer. (2008, background): “For CCL2, a large body of evidence suggests that it is indeed a potent angiogenic chemokine, and that in this respect it acts in two complementing levels [5,22,51,60,66,72–77]: (1) by increasing TAM presence at breast tumor sites, possibly followed by elevating the release of angiogenic factors by t”
• Chemokines as regulators of T cell differentiation (2001, background): “A number of chemokine receptors have been identified on tissue cells, including fibroblasts, endothelial cells and epithelial cells, which reveals further possible avenues for chemokine-mediated effects on T cell differentiatio”
• IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis1 (2003, background): “IL-8 and its receptors, CXCR1 and CXCR2, have been observed on endothelial cells (7, 8) and have been shown to play a role in endothelial cell proliferation (5).”
• Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro (2013, background): “Holding MCP-1, VEGF, and PMA constant in the source channel, we found that sprouting required S1P provided by the source channel, regardless of whether S1P was present in the endothelialized lumen.”
• Role of chemokines in tumor growth. (2007, background): “Further, neutralizing antibodies to CCL2 prevented the formation of the lung metastases in mice bearing CCL2-expressing MDA-231 human breast carcinoma xenograft [69].”