IL-8 Directly Enhanced Endothelial Cell Survival, Proliferation, and Matrix Metalloproteinases Production and Regulated Angiogenesis1

By Aihua Li, S. Dubey, M. Varney, B. Dave, Rakesh K. Singh. Journal of Immunology, 2003

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Role of Matrix Metalloproteinases in Angiogenesis and Cancer (2019, background): “TNF-α, IL-8 and other factors with a known pro-angiogenic capacity, stimulate the production of MMP-2,−8, and−9 in ECs and regulate the angiogenesis process (63, 112).”
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. (2005, background): “The proangiogenic effects of IL-8 additionally stem from its ability to inhibit the apoptosis of endothelial cells (Li et al., 2003).”
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases (2017, neutral): “For example, upon CXCL8 stimulation, endothelial cells begin the angiogenic process by secreting matrix metalloproteinases (MMPs) to break down the extracellular matrix (ECM) and start to proliferate and initiate the formation of capillaries [245].”