Derivation of midbrain dopamine neurons from human embryonic stem cells.

By A. Perrier, V. Tabar, Tiziano Barberi, M. Rubio, J. Brusés, N. Topf, Neil L Harrison, L. Studer. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,050 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a9b1d9320be288dd2fabe56f67e80b6602cae0c2

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Citations in the corpus

Isolation of amniotic stem cell lines with potential for therapy (2007, background): “Under conditions expected to bias for dopaminergic neuron”
Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD (2011, methodology): “1h) partitioned the three induction conditions into (1) LSB: dorsal forebrain; (2) LSB/S/F8: ventral/hypothalamic; (3) LSB/S/F8/CHIR: midbrain DA identity.”
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling (2009, methodology): “The dual-SMAD-inhibition protocol was compared to the standard MS5 protocol in the presence of Noggi”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “High-yield dopaminergic neuron derivation was confirmed for both human and monkey ES cell lines (266).”
Stem cells for the treatment of neurological disorders (2006, background): “For dopaminergic neurons generated from human ES cell”
Stem Cell Organoid Engineering (2016, neutral): “, 2013), midbrain dopaminergic neurons (Chambers et al., 2009; Lee et al., 2000; Perrier et al., 2004; Yan et al., 2005), and spinal cord motor neurons (Dimos et al.”
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, background): “One of the best-defined protocols for human ESC differentiation into dopamine neurons was validated in three human ESC lines and two monkey ESC lines (Perrier et al., 2004).”
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “As observed with the mouse cells, coculture of hES cells with stromal cells led to the development of neural populations with midbrain dopamine characteristics (Perrier et al. 2004; Zeng et al. 2004).”
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions. (2012, background): “, 2011), most previously published protocols derive DA neurons from cultures mainly comprised of PAX6 expressing neural progenitors (Koch et al., 2009b; Perrier et al., 2004; Roy et al., 2006; Sonntag et al., 2007; Swistowski et al., 2009).”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, methodology): “…15% FBS. Differentiation of dopaminergic neurons was performed as described previously with either an EB-based feeder-free protocol (Kim et al., 2006) or a protocol based on the combination of MS5 stromal cell coculture with the BMP antagonist Noggin (Perrier et al., 2004; Sonntag et al., 2007).”