The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

By T. M. Mathiisen, K. P. Lehre, N. Danbolt, Ole Petter Ottersen. Glia, 2010

870 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/a9953e204e2eca0790953fdc0dc8da6d9db2497b

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Citations in the corpus

A cellular perspective on brain energy metabolism and functional imaging. (2015, background): “Essentially, the entire outer surface of intraparenchymal capillaries is covered by astrocytic endfeet (Kacem et al., 1998; Simard et al., 2003), leaving only clefts of 20 nm between endfeet (Mathiisen et al., 2010).”
In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use (2016, background): “The endothelial cells and pericytes are surrounded by a basement membrane, and astrocyte endfeet ensheath the abluminal side of the capillaries with a coverage estimated at 99%.(1) Both pericytes and astrocytes regulate the phenotype of the endothelium, through mechanisms not yet fully understood bu”
Physiological roles of aquaporin-4 in brain. (2013, background): “Even if the perivascular glial processes form a continuous sheath around brain microvessels (101), these processes are not coupled by tight junctions but by gap junctional complexes that allow water to pass.”
Glutamate as a neurotransmitter in the healthy brain (2014, background): “Also note that the endfeet may actually overlap with no gaps in between them (Mathiisen et al. 2010) (Copyright: Neurotransporter AS; Reproduced with permission) Glutamate and glutamate transporters 805”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “The central nervous system (CNS) vasculature is generally regarded as being the most pericyte covered, with a 1:1–3:1 ratio between endothelial cells and pericytes, and an approximately 30% coverage of the abluminal surface (Mathiisen et al., 2010; Sims, 1986).”
The blood–brain barrier in systemic infection and inflammation (2021, background): “Although pericyte coverage of the endothelium is ~40% [55], there is an intimate association between pericytes and endothelial cells [56] such that each pericyte forms thousands of cytoplasmic extensions into endothelial cell invaginations—the molecular components and functional implications of this”
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. (2013, positive): “We surmised that overlapping astrocytic end feet, which completely ensheathe the cerebral microcirculation (8), function to restrict the access of larger molecular weight substances from the interstitium (6).”
A new look at cerebrospinal fluid circulation (2014, background): “face, leaving intercellular clefts of less than 20 nm [112].”
Physiology of Astroglia. (2018, neutral): “A characteristic feature of the CNS is the existence of a unique perivascular space created by astrocytic endfeet, which encase ~99% of the entire vasculature (1082).”