Brain-wide pathway for waste clearance captured by contrast-enhanced MRI.

By Jeffrey J. Iliff, Hedok Lee, Mei Yu, Tian Feng, Jean Logan, Maiken Nedergaard, Helene Benveniste. Journal of Clinical Investigation, 2013

996 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/98aa530db344f7fbb479ee6b00291e2147049901

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In Cellular and Molecular Neuroscience

In Neurology

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain (2013, methodology): “…al., 2012; Xie et al., 2013), by ex vivo fluorescence imaging (Yang et al., 2013), and by dynamic contrast-enhanced magnetic resonance imaging (MRI; Iliff et al., 2013; Strittmatter, 2013) that a large proportion of subarachnoid CSF rapidly re-enters the brain along paravascular pathways…”
The pathobiology of vascular dementia (2013, positive): “Images are courtesy of Dr. Hooman Kamel. has emerged as critically important for the disposal of unwanted proteins and peptides, e.g., Ab (Carare et al., 2013; Iliff et al., 2013; Laman and Weller, 2013).”
The Glymphatic System – A Beginner's Guide (2015, positive): “Using reporter mice to distinguish arteries from veins (Ds-red fluorescent protein expressed under the NG2 promoter in pericytes and smooth muscle cells) [68, 69], it was demonstrated that CSF tracers follow arteries at the pial surface running across the cortical surface and descend along penetrati”
Impairment of paravascular clearance pathways in the aging brain (2014, result): “Additionally, we have observed that at infusion rates that do not change ICP, paravascular CSF tracer flux follows the same patterns observed in the present study.(5,8) Because paravascular CSF recirculation occurs long after the normalization of ICP after the cessation of tracer infusion, the CSF t”
Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases (2017, background): “Our results are consistent with the impaired activity of the glymphatic system in AD suggested by experiments with rats [2].”
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury (2014, background): “We have defined a brain-wide paravascular pathway that facilitates the efficient clearance of interstitial proteins and peptides, including amyloid- , from the brain parenchyma (Iliff et al., 2012, 2013a,b; Xie et al., 2013).”
Glymphatic MRI in idiopathic normal pressure hydrocephalus (2017, methodology): “REF = reference subject; SU = signal unit. subarachnoid space (Iliff et al., 2012, 2013a; Bedussi et al., 2017), but contradictory to studies where intraparenchymal injection of tracers has been used (Carare et al., 2008; Bakker et al., 2016), where it was concluded with retrograde flow.”
Physiology of Astroglia. (2018, neutral): “With the use of magnetic resonance imaging (MRI) in rats (760), it was shown that clinically relevant lumbar intrathecal administration of CSF tracers permits the capture of all the key components necessary to assess glymphatic function (1914).”