A cellular perspective on brain energy metabolism and functional imaging.
By Pierre J. Magistretti, Igor Allaman. Neuron, 2015
1,129 citations recorded by the source corpus.
The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and point at a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/5422412ef48292717365807c1d50dd7887db3879
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Citations in the corpus
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- 13 reasons why the brain is susceptible to oxidative stress (2018, background): “106 ATP per mol palmitic acid vs 32 ATP per mol glucose [241], and only 14–17 ATP per mol lactate [3].”