From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.

By J. Feige, L. Gelman, L. Michalik, B. Desvergne, W. Wahli. Progress in lipid research, 2006

803 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “Given the important contribution of hepatic FAO to whole-body energy expenditure, we evaluated whether the beneficial effects of SRT1720 on muscle oxidative functions could also be observed in the liver.”
Endocrine disruptors: from endocrine to metabolic disruption. (2011, background): “In the presence of ligand, PPARs heterodimerize with RXR and bind to the PPAR response elements localized in the promoter regions of their target genes (124).”
A review on endocrine disruptors and their possible impacts on human health. (2015, background): “PPAR alpha is present in liver and when associated with the presence of endocrine disruptors mainly causes the metabolic disorders (Feige et al., 2006).”
Peroxisomes and oxidative stress. (2006, background): “Although the details of the cellular responses to activation of PPARs by their internal ligands, particularly the lipid mediators, and their effects upon cell and tissue injury and repair are just beginning to emerge [134], that information shall have a great impact on the development of novel thera”