NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

By Hongbo Zhang, D. Ryu, Yibo Wu, K. Gariani, Xu Wang, Peiling Luan, D. D’Amico, E. Ropelle, M. Lutolf, R. Aebersold and 3 more. Science, 2016

1,152 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/a1795c958703cf1c6a75d30fcea27014e9e9e0f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Guido Kroemer
2. Joseph A. Baur
3. S. Imai
4. L. Guarente

In Geriatrics and Gerontology

1. Joseph A. Baur
2. Jun Yoshino
3. S. Imai
4. K. Mills
5. Y. Sasaki
6. Alessia Grozio
7. Guido Kroemer
8. L. Guarente

In Physiology

1. Jun Yoshino
2. S. Imai
3. Joseph A. Baur
4. L. Galluzzi
5. Guido Kroemer
6. C. López‐Otín
7. D. Sinclair
8. V. Schirrmacher

Citations in the corpus

• Metabolic Control of Longevity. (2016, background): “Recently, the lifespan-extending effects of nicotinamide riboside have been linked to the activation of the UPRmt in various stem cell compartments in mice (Zhang et al., 2016), suggesting that the UPRmt may be important for longevity in several organisms beyond worms.”
• Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice (2016, positive): “…al., 2014), attenuate cognitive deterioration in Alzheimer’s diseasemodel mice (Gong et al., 2013), prevent DNA damage and hepatocellular carcinoma formation (Tummala et al., 2014), improve noise-induced hearing loss (Brown et al., 2014), and maintain muscle stem cell function (Zhang et al., 2016).”
• Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health (2017, background): “Nevertheless, NAD boosting strategies seem to be successful in restoringmitochondrial and stem cell function (121) and in ameliorating diseases such as muscular dystrophy and diabetes (122, 123) or even prolonging life span (124).”
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “Indeed, genetic and pharmacological replenishment of NAD improves the age-related biologic function and increases lifespan at least in worms and mice.(341,342) The increased expression of NAMPT in aging human SMCs prolonged lifespan via delaying senescence and enhancing resistance to oxidative stres”