RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

By C. Hoege, B. Pfander, George‐Lucian Moldovan, George Pyrowolakis, S. Jentsch. Nature, 2002

2,328 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a8d30a9f4a4d11a40f84dc7f1215defc90898d25

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Citations in the corpus

Ubiquitin: structures, functions, mechanisms. (2004, background): “It is also a non-proteolytic signal in subnuclear trafficking [20], DNA damage tolerance [21], and several other processes (see Refs.”
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO (2004, background): “As UBC13 and MMS2 form an E2 complex that functions with certain E3 ubiquitin ligases such as TRAF2, TRAF6, or RAD5 to catalyse K63-linked polyubiquitinatio”
How the fanconi anemia pathway guards the genome. (2009, background): “Finally, it is attractive to imagine that modified FANCD2-I can enhance the activity of repair enzymes, perhaps by localizing them to their substrate (Figure 4c), in analogy to PCNA ubiquitination-dependent recruitment of TLS polymerases (63, 96).”
Ubiquitylation and cell signaling (2005, background): “SUMO (small Ub-like modifier) attachment to PCNA is involved in normal DNA synthesis during S phase (Hoege et al, 2002).”
Regulation of DNA repair throughout the cell cycle (2008, background): “In budding yeast, both pathways depend on the RAD6–RAD18 post-replication repair (PRR) pathway and are largely controlled through covalent modifications of proliferating cell nuclear antigen (PCNA; an essential processivity clamp for DNA polymerases) by ubiquiti”
Ubiquitin and ubiquitin-like proteins as multifunctional signals (2005, background): “cerevisiae , it now seems that all three mechanisms of DNA repair are brought about by the modification of the same residue (K164) in the proliferating cell nuclear antigen (PCNA) DNA-replication processivity facto”
Y-family DNA polymerases and their role in tolerance of cellular DNA damage (2012, neutral): “PCNA mono-ubiquitylation is principally mediated by the E3 ubiquitin ligase RAD18 acting in concert with the E2 ubiquitin-conjugating enzyme RAD6 (Ref”