Ubiquitin: structures, functions, mechanisms.

By C. Pickart, M. Eddins. Biochimica et Biophysica Acta, 2004

1,440 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8ef0307e104aae9a3a44b40c9e64e89bc2515435

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In Molecular Biology

Citations in the corpus

Ubiquitin-binding domains — from structures to functions (2009, background): “Conjugation of ubiquitin to a target protein or to itself is regulated by the sequential activity of ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligating (E3) enzymes, and it typically results in the addition of a ubiquitin moiety either to the e-amino group of a Lys residue ”
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis (2013, background): “The attachment of Ub is accomplished by three enzymes: an E1 Ub-activating enzyme, an E2 Ub-conjugating enzyme, and an E3 Ub ligase (1).”
Ubiquitin-binding domains (2005, background): “org/uniprot/P62988">ubiquitin — is covalently attached to free amino groups on lysine side chains or to the N-terminal amino group of a target protei”
Reading protein modifications with interaction domains (2006, background): “Ubiquitylation is inducible (for example, by growth factors, cytokines, DNA damage and cell-cycle transitions), reversible, and occurs through the regulated function of ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligase (E3) enzyme”
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, neutral): “"”
TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases (2005, background): “The E3 ubiquitin ligases are divided into three distinct classes based on the catalytic domain mediating ubiquitin transfer: HECT (Homologous to E6AP Carboxy Terminus)-, U-box- and RING finger-containing E3s.”
Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling (2008, background): “In contrast to two Ub E1 and the estimated fewer than 40 Ub E2 genes (our unpublished observations and [1]) and consistently with the role of E3s in conferring substrate specificity to ubiquitylation, we uncovered ,617 genes encoding putative Ub E3s after searching a human proteome superset and anno”