Particle size-dependent organ distribution of gold nanoparticles after intravenous administration.

By W. D. De Jong, W. Hagens, P. Krystek, M. C. Burger, A. Sips, R. Geertsma. Biomaterials, 2008

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How researchers see this paper

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Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “Size can affect both the distribution within the body as well as the distribution within a cell [203,204].”
The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles (2012, background): “intestine by persorption and further distribute into the blood, brain, kidney, and liver [77,78].”
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? (2010, positive): “Their data showed that the smallest size (10 nm) nanoparticles were found in the blood, spleen, liver, testis, lung, and brain; the larger sizes were found only in spleen and kidney (De Jong et al. 2008).”
Airborne microplastics: Consequences to human health? (2018, positive): “Nanoplastics could be compared to other insoluble nanoparticles, such as gold and titanium oxide (Bouwmeester et al., 2015) both known to suffer translocation (De Jong et al., 2008; Shi et al., 2013).”