Mucus clearance as a primary innate defense mechanism for mammalian airways.

By M. Knowles, R. Boucher. Journal of Clinical Investigation, 2002

1,259 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/a86186eae9f0a03f27b3128c82d7a4645912b353

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. T. Bjarnsholt
2. Robert E. W. Hancock

In Pulmonary and Respiratory Medicine

1. T. Bjarnsholt
2. Robert E. W. Hancock
3. S. Gellatly
4. S. Randell

Citations in the corpus

• The role of bacterial biofilms in chronic infections (2013, background): “, recurrent or chronic bacterial lung infections (255, 261) (see Fig.”
• Pathophysiology and management of pulmonary infections in cystic fibrosis. (2003, background): “Clearance of particles from normal peripheral airways by mucociliary clearance can require up to 6 hours, and this can be significantly prolonged in CF airways (66).”
• Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. (2013, background): “…side chains of the mucins to improperly unfold, hampering their ability to bind foreign particles, and making them more likely to bind to the celltethered mucins MUC1 and MUC4, thus effectively gluing the mucous layer to the epithelium and preventing mucociliary clearance (Knowles & Boucher, 2002).”
• Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. (2002, background): “Thus, we speculate that mucus clearance is a key feature of innate lung defense (44), and a fundamental defect leading to chronic CF lung infections is the failure to effectively clear mucus that contains bound bacteria from the lung (10).”
• Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues (2008, background): “Filtered particles are removed from the airways by mucociliary clearance and become sterilized by gastric acid [14,89].”
• Micro- and macrorheology of mucus (2009, neutral): “Rapid mucus clearance in the respiratory tract, from the lung airways and sinuses towards the pharynx and stomach for eventual gastric sterilization and digestion, is an important component of the mucosal defense against foreign pathogens [1].”
• Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice (2004, background): “In cystic fibrosis, the absence of these CFTR functions is predicted to result in increased Na + and water (volume) absorption, depletion of ASL volume, impaired mechanical clearance of mucus, and infectio”