Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients.

By D. Worlitzsch, R. Tarran, M. Ulrich, U. Schwab, Aynur Cekici, K. Meyer, P. Birrer, G. Bellon, J. Berger, T. Weiss and 5 more. Journal of Clinical Investigation, 2002

1,278 citations recorded by the source corpus.

Subfields: Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/7c0957a395239c5eed7997a3f291bbcae589db6b

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In Pulmonary and Respiratory Medicine

1. T. Bjarnsholt
2. Robert E. W. Hancock

Citations in the corpus

• Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. (2002, background): “Recently, Worlitzsch et al. (2002) demonstrated in potentially protective NOR activity in the rhlR mutantthat steep hypoxic gradients are present in stationary cannot provide relief from such toxic NO levels.”
• Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum (2007, background): “aeruginosa forms microcolony structures in vivo (28, 67); thus, SCFM biofilm studies would necessitate mucin addition to mimic the natural viscosity.”
• The Microbiome and the Respiratory Tract (2015, background): “Mucus production results in local pockets of anoxia (52) and increased temperature (53), both of which selectively favor the growth of certain community members.”
• The Changing Microbial Epidemiology in Cystic Fibrosis (2010, background): “gradients and fully anaerobic conditions in the lungs of CF patients (354, 360) and the identification of anaerobic species”
• Pathophysiology and management of pulmonary infections in cystic fibrosis. (2003, background): “Although there is no evidence of any deficiency in antimicrobial peptides in CF, it has been hypothesized (67, 478) that either the raised ionic content of the airway surface fluid in this disorder may inactivate these salt-sensitive peptides or the slowed mucociliary clearance (97) may overwhelm th”
• Bacterial Biofilm and its Role in the Pathogenesis of Disease (2020, background): “Microscopic analyses have shown that P. aeruginosa in sputum grows as microcolonies adherent to sputum components [195] .”
• The role of bacterial biofilms in chronic infections (2013, background): “Like chronic wounds, CF was believed to be a biofilm disease (32, 79, 216).”
• Bacterial biofilms: from the Natural environment to infectious diseases (2004, background): “Recently, Worlitzsch et al.(124) studied CF patients with chronic lung disease directly using electron microscopy and tissue explants, and found that P.”
• Evolving concepts in biofilm infections (2009, background): “P. aeruginosa was found in bacterial aggregates enclosed in a matrix within O2-depleted mucus from CF patients, although not necessarily adherent to the airway epithelium (Worlitzsch et al., 2002).”
• Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles (2009, background): “If OMV modulate host physiology of lung cells without direct bacteria-host contact, we would predict that OMV secreted by bacteria should overcome barriers such as the mucus overlying human airway cells [23].”
• Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa (2013, background): “However it is not exactly clear how RNase E activity is stimulated by double-stranded RNA regions, though it is presumed that the 5’ end of an base-pairing sRNA could provide a monophosphate, which has been shown to stimulate RNase E activity (51).”