Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

By Jason K. Kim, Jonathan J. Fillmore, Yan Chen, Chun-lian Yu, Irene K. Moore, M. Pypaert, E. P. Lutz, Yuko Kako, W. Vélez-Carrasco, I. Goldberg and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2001

741 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a84a9ecb23ebeffcf843a7203ba0dfc130b09f2e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

In Molecular Biology

In Physiology

Citations in the corpus

Lipoprotein lipase: from gene to obesity. (2009, background): “When LPL is overexpressed in the liver in mice, a twofold increase in liver TG content and insulin resistance is observed (119).”
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. (2016, background): “Similarly, mice overexpressing LpL in the liver develop hepatic steatosis and liver-specific insulin resistance (65).”
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. (2002, positive): “In the livers of both lipodystrophic mice (19) and transgenic mice with steatosis due to over-expression of lipoprotein lipase (20), decreased insulin activation of IRS-2–associated phosphatidylinositol 3-kinase activity was observed.”
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. (2002, positive): “In support of fatty acids being an important factor in this regard, recent studies have demonstrated a strong relationship between tissue lipid content and insulin resistance in both skeletal muscle (14–20) and liver (15,16,21).”
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. (2002, background): “(39) recently demonstrated that transgenic overexpression of lipoprotein lipase in skeletal muscle caused insulin resistance in nondiabetic mice.”
Non-Alcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases (2017, positive): “Similarly, mice overexpressing LpL in the liver develop hepatic steatosis and liver-specific insulin resistance (Kim et al., 2001).”
Energy Metabolism in the Liver (2014, positive): “Transgenic mice with liver-specific overexpression of LPL develop hepatic steatosis and insulin resistance (114).”
Insulin Resistance: From Mechanisms to Therapeutic Strategies (2021, background): “In addition, overexpression of lipoprotein lipase (LPL) in liver or muscle induced peripheral insulin resistance and the accumulation of lipid in respective tissues [87,88], and skeletal muscle-specific LPL deletion enhanced”