Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey.

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Regulation of NF-κB by TNF Family Cytokines (2014, background): “TNF signals through two receptors, TNFR1 (p55; TNFR1a) and TNFR2 (p75; TNFR1b) [21].”
Regulation of tumour necrosis factor signalling: live or let die (2015, methodology): “However, based on its structure, TNFR1 is classified as a death receptor and classical apoptosis was shown to occur upon TNF binding to TNFR1 (REFS 2,3) .”
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics (2021, background): “The functional outcome of complex I signaling is known to be the induction of inflammation, tissue, cell survival and proliferation, and the immune defense against pathogens [12,16].”