Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.

By Yujing Liu, R. Wada, T. Yamashita, Yide Mi, C. Deng, J. P. Hobson, Hans M. Rosenfeldt, V. Nava, Sung-suk Chae, M. Lee and 4 more. Journal of Clinical Investigation, 2000

1,207 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a80c26454b114f431003de6566e0cfa055935c6e

How researchers see this paper

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In Cell Biology

1. LM Obeid
2. Yusuf A. Hannun
3. B. Ogretmen
4. J. Cyster
5. Susan R. Schwab
6. S. Milstien
7. Sarah Spiegel
8. R. Adams

In Molecular Biology

1. Sarah Spiegel
2. Yusuf A. Hannun
3. B. Ogretmen
4. Susan R. Schwab
5. J. Cyster
6. LM Obeid
7. S. Milstien
8. A. Armulik

Citations in the corpus

• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Binding of plasma-borne bioactive lipid sphingosine-1-phosphate to the endothelial-specific G protein-coupled receptor S1P1 (Edg1) is critical for the mural cell recruitment to the developing dorsal aorta and its proximal branches (Allende and Proia, 2002; Allende et al., 2003; Liu et al., 2000).”
• THE ALLIANCE OF SPHINGOSINE-1-PHOSPHATE AND ITS RECEPTORS IN IMMUNITY (2008, background): “Further support is provided by the well-documented role of S1PR1 in regulating endothelial-cell organization during developmen”
• An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “In addition, the vascular defects observed in the double knockout mice resembled previously observed defects in S1P1 receptor knockout mice, suggesting that S1P is absolutely necessary for vascular development [136], [135].”
• The outs and the ins of sphingosine-1-phosphate in immunity (2011, positive): “In agreement with this role for RAC as a downstream effector of S1PR1-mediated migratio”
• Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “Embryonic mice lacking S1P 1 in all lineages die midgestation due to vascular defect”
• Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. (2001, background): “Recently, Edg-1–deficient mouse embryos were noted to display significant abnormalities in vascular development, rendering the newly formed vessels leaky, resulting in fluid extravasation and hemorrhage (18).”